Calixto E, Montiel T, Lemini C, Brailowsky S
Departamento de Neurociencias, Universidad Nacional Autónoma de México, D.F., Mexico.
Neurosci Lett. 1995 Aug 4;195(2):73-6. doi: 10.1016/0304-3940(95)11747-k.
We have studied the neuromodulatory effect of the neurosteroid 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone-3 alpha-5 alpha P-) in the GABA-withdrawal syndrome (GWS). This is a model of partial epilepsy consisting of an enduring paraoxysmal activity recorded at the site of GABA infusion that depends, for its induction, on GABA receptor activation. Rats were chronically implanted for frontal and occipital EEG recording with infusion cannulae fixed on the somatomotor cortical region. When the neurosteroid was infused after or concurrently with GABA, a potentiation of the GWS (i.e. shorter latency and prolonged duration) was observed. No modifications in EEG activity were detected when allopregnanolone was administered alone or prior to GABA administration. These results indicate a neuromodulatory effect of allopregnanolone, dependent on the presence of GABA at the receptor site.
我们研究了神经甾体3α-羟基-5α-孕烷-20-酮（别孕烯醇酮-3α-5αP-）在GABA戒断综合征（GWS）中的神经调节作用。这是一种部分性癫痫模型，由在GABA注入部位记录到的持续性阵发性活动组成，其诱发依赖于GABA受体激活。将大鼠长期植入用于额叶和枕叶脑电图记录，输液套管固定在躯体运动皮质区域。当神经甾体在GABA之后或同时注入时，观察到GWS增强（即潜伏期缩短和持续时间延长）。单独给予别孕烯醇酮或在给予GABA之前给予别孕烯醇酮时，未检测到脑电图活动的改变。这些结果表明别孕烯醇酮具有神经调节作用，该作用依赖于受体部位GABA的存在。
