Ferri G L, Zareh S, Amadori A, Bastone A, Sbraccia M, Dahl D, Frontali N
Department of Anatomy, 'Tor Vergata' University, Rome, Italy.
Brain Res. 1988 Mar 22;444(2):383-8. doi: 10.1016/0006-8993(88)90952-3.
In rats intoxicated with 2,5-hexanedione, nerve fibres supplying virtually all visceral organs showed large numbers of densely immunoreactive accumulations of neurofilament-like material, of fusiform, elongated, smoothly tapering morphology. In the gut, round to oval, morphologically different lesions were also present, and abnormal neurofilament-immunoreactive accumulations were revealed in oesophageal terminal end-plates. An extensive damage to autonomic nerve fibres, which are largely non-myelinated, was thus revealed in 2,5-hexanedione intoxication. The observed diversity in lesion morphology may suggest heterogeneity in cytoskeletal and/or associated proteins among autonomic neurons.
在2,5 -己二酮中毒的大鼠中，几乎为所有内脏器官供血的神经纤维显示出大量神经丝样物质的密集免疫反应性积聚，呈梭形、细长形，形态逐渐变细。在肠道中，还存在圆形至椭圆形、形态不同的病变，并且在食管终板中发现了异常的神经丝免疫反应性积聚。因此，在2,5 -己二酮中毒中发现了对主要为无髓鞘的自主神经纤维的广泛损伤。观察到的病变形态多样性可能表明自主神经元中细胞骨架和/或相关蛋白存在异质性。
