Rossi A, Simonati A, Rizzuto N, Toschi G
Brain Res. 1982 Jul 15;243(2):373-7. doi: 10.1016/0006-8993(82)90264-5.
In rats treated for 14 days with 2,5-hexanedione, the efficiency of ganglionic transmission was markedly reduced whereas only faint ultrastructural changes occurred in a few preganglionic fibers; evident signs of axonal pathology were observed on the 30th day of treatment. Choline acetyltransferase activity and acetylcholine formation showed no alteration at any time. The autonomic system is affected early during 2,5-hexanedione neuropathy, functional changes being more marked than morphological lesions.
在用2,5 -己二酮处理14天的大鼠中，神经节传递效率显著降低，而少数节前纤维仅出现轻微的超微结构变化；在处理的第30天观察到明显的轴突病变迹象。胆碱乙酰转移酶活性和乙酰胆碱生成在任何时候都没有改变。自主神经系统在2,5 -己二酮神经病变早期就受到影响，功能变化比形态学损伤更明显。
