National Institute of Hygiene and Epidemiology (NIHE), 1 - Yersin Street, Hanoi, Vietnam.
Department of Life Science, College of Natural Sciences, Hanyang University, Seoul 04763, Korea.
Anticancer Agents Med Chem. 2020;20(11):1276-1287. doi: 10.2174/1871520619666190710121727.
Silver nanoparticles (AgNPs) are well-known as a promising antimicrobial material; they have been widely used in many commercial products against pathogenic agents. Despite a growing concern regarding the cytotoxicity, AgNPs still have attracted considerable interest worldwide to develop a new generation of diagnostic tool and effective treatment solution for cancer cells.
This paper aims to review the advances of AgNPs applied for cancer diagnosis and treatment.
The database has been collected, screened and analysed through up-to-date scientific articles published from 2007 to May 2019 in peer-reviewed international journals.
The findings of the database have been analysed and divided into three parts of the text that deal with AgNPs in cancer diagnosis, their cytotoxicity, and the role as carrier systems for cancer treatment. Thanks to their optical properties, high conductivity and small size, AgNPs have been demonstrated to play an essential role in enhancing signals and sensitivity in various biosensing platforms. Furthermore, AgNPs also can be used directly or developed as a drug delivery system for cancer treatment.
The review paper will help readers understand more clearly and systematically the role and advances of AgNPs in cancer diagnosis and treatment.
银纳米粒子（AgNPs）作为一种有前途的抗菌材料而广为人知；它们已被广泛应用于许多针对病原体的商业产品中。尽管人们越来越关注其细胞毒性，但 AgNPs 仍在全球范围内引起了相当大的兴趣，以开发新一代用于癌症诊断的工具和有效的治疗方法。
本文旨在综述 AgNPs 在癌症诊断和治疗中的应用进展。
通过对 2007 年至 2019 年 5 月期间在同行评审的国际期刊上发表的最新科学文章进行收集、筛选和分析，建立了数据库。
对数据库的结果进行了分析，并分为三部分，分别涉及 AgNPs 在癌症诊断中的应用、它们的细胞毒性以及作为癌症治疗载体系统的作用。由于其光学特性、高导电性和小尺寸，AgNPs 已被证明在增强各种生物传感平台的信号和灵敏度方面发挥了重要作用。此外，AgNPs 还可以直接用于癌症治疗，或开发为药物输送系统。
综述论文将帮助读者更清楚、更系统地了解 AgNPs 在癌症诊断和治疗中的作用和进展。
