Department of Pathophysiology, Guangdong Key Laboratory of Genome Stability and Human Disease Prevention, Shenzhen University Health Science Center, Shenzhen, Guangdong, China.
Department of Endocrinology, The Second Clinical Medical College of Jinan University, Shenzhen People's Hospital, Shenzhen, Guangdong, China; Clinical Medical Research Center, The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, China.
Can J Cardiol. 2019 Jul;35(7):923-930. doi: 10.1016/j.cjca.2019.04.007. Epub 2019 Apr 16.
Inflammation is closely related to the pathogenesis and prognosis of cardiovascular disease (CVD). Interleukin-37 (IL-37), an anti-inflammatory IL-1 family cytokine, shifts cytokine expression from pro- to anti-inflammation via regulation of macrophage polarization and lipid metabolism. In macrophages, IL-37 functions through both intracellular and extracellular pathways to regulate the activity of NF-kB and PTEN as well as the expression of cytokines, including IL-1β, IL-6, and IL-10. Moreover, IL-37 levels are increased in the serum of patients with heart failure, atherosclerosis, and acute coronary syndrome with no evidence of anti-inflammatory effects. However, transgenic overexpression of IL-37 improves cardiac infarct and attenuates atherosclerosis plaque expansion. Hence, it is worthwhile to investigate the precise mechanism and role of IL-37 in the pathogenesis of CVD, which may provide deeper understanding of the inflammatory response in this context. This review summarizes the regulatory role of IL-37 in systematic inflammation induced by CVD and highlights recent advancements in the clinical application of IL-37 as a therapeutic agent or biomarker for diagnosis of CVD.
炎症与心血管疾病（CVD）的发病机制和预后密切相关。白细胞介素-37（IL-37）是一种抗炎性白细胞介素-1 家族细胞因子，通过调节巨噬细胞极化和脂质代谢，将细胞因子的表达从促炎转变为抗炎。在巨噬细胞中，IL-37 通过细胞内和细胞外途径发挥作用，调节 NF-kB 和 PTEN 的活性以及细胞因子的表达，包括 IL-1β、IL-6 和 IL-10。此外，心力衰竭、动脉粥样硬化和急性冠状动脉综合征患者的血清中 IL-37 水平升高，但没有抗炎作用的证据。然而，IL-37 的转基因过表达可改善心肌梗死并减轻动脉粥样硬化斑块扩张。因此，研究 IL-37 在 CVD 发病机制中的精确机制和作用是值得的，这可能为理解这方面的炎症反应提供更深入的认识。本综述总结了 IL-37 在 CVD 引起的系统性炎症中的调节作用，并强调了 IL-37 作为治疗剂或 CVD 诊断生物标志物的临床应用的最新进展。
