Teng Zhen, Wei Meiyu
Cardiovascular Department IV, Cangzhou Central Hospital Cangzhou, China.
Cardiovascular Department III, Cangzhou Central Hospital Cangzhou, China.
Am J Transl Res. 2021 Jul 15;13(7):8379-8384. eCollection 2021.
To test the relationship between serum 25-hydroxyvitamin D[25(OH)D], interleukin-6 (IL-6), and the severity of coronary heart disease (CHD).
A total of 150 patients with suspected myocardial ischemia presenting to our hospital from January 2018 to January 2020 were recruited. All patients underwent percutaneous coronary angiography (CAG). According to CAG results, they were divided into normal group (n=40) and CHD group (n=110). According to the coronary Gensini score, CHD patients were divided into 62 cases in the low-risk group (< 20 points), 31 cases in the moderate-risk group (20-40 points), and 17 cases in the high-risk group (> 40 points). The Gensini scores and serum 25(OH)D and IL-6 levels in each group were recorded, and the correlation between the serum 25(OH)D and IL-6 levels and the severity of the disease was analyzed. The Essen Stroke Risk Scale (ESRS) was evaluated and compared between the two groups.
The serum 25(OH)D, IL-6 level, and ESRS score in the CHD group and the normal group statistically differed (P < 0.05). In the CHD group, Gensini score, serum IL-6 level and ESRS score increased with the increase of coronary artery stenosis, and 25(OH)D level decreased with the increase of coronary artery stenosis, and all the differences were significant (P < 0.05). Pearson correlation analysis demonstrated that serum IL-6 levels in patients with CHD are positively correlated with the severity of the disease (r=0.724, P < 0.001), and 25(OH)D levels are in a negative relation (r=-0.522, P < 0.001).
A decrease of serum 25(OH)D level and increase in IL-6 level in patients with CHD are associated with the severity of CHD. This may provide a reference for clinical diagnosis, treatment, and prognosis.
检测血清25-羟维生素D[25(OH)D]、白细胞介素-6（IL-6）与冠心病（CHD）严重程度之间的关系。
选取2018年1月至2020年1月在我院就诊的150例疑似心肌缺血患者。所有患者均接受经皮冠状动脉造影（CAG）。根据CAG结果，将其分为正常组（n = 40）和CHD组（n = 110）。根据冠状动脉Gensini评分，将CHD患者分为低风险组（<20分，62例）、中风险组（20 - 40分，31例）和高风险组（>40分，17例）。记录每组的Gensini评分以及血清25(OH)D和IL-6水平，并分析血清25(OH)D和IL-6水平与疾病严重程度之间的相关性。对两组进行Essen卒中风险量表（ESRS）评估与比较。
CHD组和正常组的血清25(OH)D、IL-6水平及ESRS评分差异有统计学意义（P < 0.05）。在CHD组中，Gensini评分、血清IL-6水平及ESRS评分随冠状动脉狭窄程度增加而升高；25(OH)D水平随冠状动脉狭窄程度增加而降低，且差异均有统计学意义（P < 0.05）。Pearson相关分析表明，CHD患者血清IL-6水平与疾病严重程度呈正相关（r = 0.724，P < 0.001），25(OH)D水平呈负相关（r = -0.522，P < 0.001）。
CHD患者血清25(OH)D水平降低及IL-6水平升高与CHD严重程度相关。这可能为临床诊断、治疗及预后提供参考。
