谜题、承诺与衰老的治愈方法。
Puzzles, promises and a cure for ageing.
作者信息
Vijg Jan, Campisi Judith
机构信息
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945, USA.
出版信息
Nature. 2008 Aug 28;454(7208):1065-71. doi: 10.1038/nature07216.
Abstract
Recent discoveries in the science of ageing indicate that lifespan in model organisms such as yeast, nematodes, flies and mice is plastic and can be manipulated by genetic, nutritional or pharmacological intervention. A better understanding of the targets of such interventions, as well as the proximate causes of ageing-related degeneration and disease, is essential before we can evaluate if abrogation of human senescence is a realistic prospect.
摘要
衰老科学领域的最新发现表明，酵母、线虫、果蝇和小鼠等模式生物的寿命具有可塑性，可以通过基因、营养或药物干预来调控。在我们评估消除人类衰老是否是一个现实的前景之前，更好地了解这些干预的靶点以及与衰老相关的退化和疾病的直接原因至关重要。
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