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基于多光子吸收光解 2-硝基苄基聚乙二醇的核壳金纳米星-介孔硅纳米粒子的近红外光触发药物传递系统。

A NIR light-triggered drug delivery system using core-shell gold nanostars-mesoporous silica nanoparticles based on multiphoton absorption photo-dissociation of 2-nitrobenzyl PEG.

机构信息

Instituto Interuniversitario de Investigación de Reconocimiento Molecular y Desarrollo Tecnológico, Universitat Politècnica de València, Universitat de València, Spain.

Facultad de Química, Universidad de La Habana, 10400 La Habana, Cuba.

出版信息

Chem Commun (Camb). 2019 Aug 7;55(61):9039-9042. doi: 10.1039/c9cc04260a. Epub 2019 Jul 11.

DOI:10.1039/c9cc04260a
PMID:31292589
Abstract

Gold nanostars coated with a mesoporous silica shell and functionalized with poly(ethylene glycol) containing photolabile 2-nitrobenzyl moieties are able to release doxorubicin after NIR light irradiation at low power irradiance via a multiphoton absorption photo-dissociation process.

摘要

金纳米星表面包覆介孔硅壳并通过聚乙二醇功能化，其中聚乙二醇连接有光解 2-硝基苄基部分，在低功率光强的近红外光照射下，通过多光子吸收光解过程，可以释放阿霉素。

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