Cheng Bei, Xu Peisheng
Department of Drug Discovery & Biomedical Sciences, University of South Carolina, 609A, 715 Sumter St., Columbia, SC, 29208, USA.
Methods Mol Biol. 2017;1530:117-123. doi: 10.1007/978-1-4939-6646-2_7.
Various gold nanoparticles have been explored in biomedical systems and proven to be promising in photothermal therapy and drug delivery. Among them, nanoshells were regarded as traditionally strong near infrared absorbers that have been widely used to generate photothermal effect for cancer therapy. However, the nanoshell is not photo-thermal stable and thus is not suitable for repeated irradiation. Here, we describe a novel discrete gold nanostructure by mimicking the continuous gold nanoshell-gold/mesoporous silica hybrid nanoparticle (GoMe). It possesses the best characteristics of both conventional gold nanoparticles and mesoporous silica nanoparticles, such as excellent photothermal converting ability as well as high drug loading capacity and triggerable drug release.
各种金纳米颗粒已在生物医学系统中得到探索，并被证明在光热疗法和药物递送方面具有潜力。其中，纳米壳被认为是传统的强近红外吸收剂，已被广泛用于产生光热效应以进行癌症治疗。然而，纳米壳的光热稳定性不佳，因此不适合重复照射。在此，我们通过模仿连续的金纳米壳-金/介孔二氧化硅杂化纳米颗粒（GoMe）描述了一种新型离散金纳米结构。它兼具传统金纳米颗粒和介孔二氧化硅纳米颗粒的最佳特性，如优异的光热转换能力以及高载药量和可触发的药物释放。
