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儿童不可切除复发性恶性骶尾部畸胎瘤的放化疗治疗:病例报告及文献综述

Unresectable recurrence malignant sacrococcygeal teratoma in children treated with chemoradiotherapy: Case report and literature review.

作者信息

Huang Yecai, Feng Mei, Yin Jun, Fu Bingyu, Lang Jinyi

机构信息

Department of Radiation Oncology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

出版信息

Rep Pract Oncol Radiother. 2019 Jul-Aug;24(4):392-398. doi: 10.1016/j.rpor.2019.06.002. Epub 2019 Jun 22.

DOI:10.1016/j.rpor.2019.06.002
PMID:31293363
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6595120/
Abstract

Sacrococcygeal teratoma is the most common germ cell neoplasia that consists of tissues derived from primitive germ layers. Approximately 10-20% of patients are malignant. Because of the high rate of recurrence, treatment strategies for malignant sacrococcygeal teratomas are limited. Hence, we report a case of malignant sacrococcygeal teratoma treated with concurrent chemoradiotherapy plus adjuvant chemotherapy and review the literature. This case report indicates that chemoradiation plus adjuvant chemotherapy may be a treatment option for malignant SCT which is not technically resectable or with residual lesion after surgery.

摘要

骶尾部畸胎瘤是最常见的生殖细胞肿瘤,由源自原始胚层的组织构成。约10%-20%的患者为恶性。由于复发率高,恶性骶尾部畸胎瘤的治疗策略有限。因此,我们报告1例采用同步放化疗加辅助化疗治疗的恶性骶尾部畸胎瘤病例并复习文献。本病例报告表明,放化疗加辅助化疗可能是无法进行手术切除或术后有残留病灶的恶性骶尾部畸胎瘤的一种治疗选择。

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本文引用的文献

1
High-dose Chemotherapy is Efficacious and Well Tolerated in a Toddler With Aicardi Syndrome and Malignant Sacrococcygeal Teratoma.高剂量化疗对一名患有艾卡迪综合征和恶性骶尾部畸胎瘤的幼儿有效且耐受性良好。
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Multi-stage resection and repair for the treatment of adult giant sacrococcygeal teratoma: A case report and literature review.多阶段切除与修复治疗成人巨大骶尾部畸胎瘤:1例病例报告及文献复习
Oncol Lett. 2015 Jul;10(1):425-429. doi: 10.3892/ol.2015.3249. Epub 2015 May 20.
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Malignant transformation in sacrococcygeal teratoma and in presacral teratoma associated with Currarino syndrome: a comparative study.骶尾部畸胎瘤及与库拉里诺综合征相关的骶前畸胎瘤的恶性转化:一项比较研究。
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Sacrococcygeal teratoma with nephroblastic elements: a case report and review of literature.伴有肾母细胞瘤成分的骶尾部畸胎瘤:一例报告并文献复习
Int J Clin Exp Pathol. 2014 Oct 15;7(11):8211-6. eCollection 2014.
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Sacro-coccygeal teratoma in adult: Two rare case reports and review of literature.成人骶尾部畸胎瘤:两例罕见病例报告及文献复习
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7
Diagnosis of sacrococcygeal teratoma using two and three-dimensional ultrasonography: two cases reported and a literature review.二维和三维超声检查在骶尾部畸胎瘤诊断中的应用:两例报告并文献复习
Med Ultrason. 2014 Sep;16(3):274-7. doi: 10.11152/mu.2013.2066.163.mg1gi2.
8
Two cases of prenatally diagnosed sacrococcygeal teratoma type I with different clinical features.两例产前诊断的 I 型骶尾部畸胎瘤,具有不同临床特征。
Congenit Anom (Kyoto). 2013 Jun;53(2):92-4. doi: 10.1111/j.1741-4520.2012.00369.x.
9
High prevalence of sacrococcygeal teratoma in Finland - a nationwide population-based study.芬兰尾骨畸胎瘤的高发率——一项全国基于人群的研究。
Acta Paediatr. 2013 Jun;102(6):e251-6. doi: 10.1111/apa.12211. Epub 2013 Mar 25.
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Sacrococcygeal teratoma in infants and children.骶尾部畸胎瘤。
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