Monitoring the Early Antiproliferative Effect of the Analgesic-Antitumor Peptide, BmK AGAP on Breast Cancer Using Intravoxel Incoherent Motion With a Reduced Distribution of Four -Values.

The present study aimed to investigate the possibility of using intravoxel incoherent motion (IVIM) diffusion magnetic resonance imaging (MRI) to quantitatively assess the early therapeutic effect of the analgesic-antitumor peptide BmK AGAP on breast cancer and also evaluate the medical value of a reduced distribution of four -values. IVIM diffusion MRI using 10 -values and 4 -values (0-1,000 s/mm) was performed at five different time points on mice bearing xenograft breast tumors treated with BmK AGAP. Variability in , , , and derived from the set of 10 -values and 4 -values was assessed to evaluate the antitumor effect of BmK AGAP on breast tumor. The data showed that values significantly decreased in rBmK AGAP-treated mice on day 12 ( = 0.044). displayed the greatest AUC but with a poor medical value (AUC = 0.65). The data showed no significant difference between IVIM measurements acquired from the two sets of -values at different time points except in the on the day 3. The within-subject coefficients of variation were relatively higher in and . However, except for a case noticed on day 0 in measurements, the results indicated no statistically significant difference at various time points in the rBmK AGAP-treated or the untreated group ( < 0.05). IVIM showed poor medical value in the early evaluation of the antiproliferative effect of rBmK AGAP in breast cancer, suggesting sensitivity in . A reduced distribution of four b-values may provide remarkable measurements but with a potential loss of accuracy in the perfusion-related parameter .