STAT3 对 I 型干扰素反应的精细调控。
Fine-Tuning of Type I Interferon Response by STAT3.
机构信息
Graduate Institute of Immunology, National Taiwan University College of Medicine, Taipei, Taiwan.
Department of Biochemistry and Molecular Biology, Chang Gung University, Taoyuan, Taiwan.
出版信息
Front Immunol. 2019 Jun 26;10:1448. doi: 10.3389/fimmu.2019.01448. eCollection 2019.
Type I interferon (IFN-I) is induced during innate immune response and is required for initiating antiviral activity, growth inhibition, and immunomodulation. STAT1, STAT2, and STAT3 are activated in response to IFN-I stimulation. STAT1, STAT2, and IRF9 form ISGF3 complex which transactivates downstream IFN-stimulated genes and mediates antiviral response. However, the role of STAT3 remains to be characterized. Here, we review the multiple actions of STAT3 on suppressing IFN-I responses, including blocking IFN-I signaling, downregulating the expression of ISGF3 components, and antagonizing the transcriptional activity of ISGF3. Finally, we discuss the evolution of the suppressive activity of STAT3 and the therapeutic potential of STAT3 inhibitors in host defense against viral infections and IFN-I-associated diseases.
I 型干扰素 (IFN-I) 在固有免疫反应中被诱导产生，对于启动抗病毒活性、生长抑制和免疫调节是必需的。STAT1、STAT2 和 STAT3 在受到 IFN-I 刺激时被激活。STAT1、STAT2 和 IRF9 形成 ISGF3 复合物，该复合物可反式激活下游 IFN 刺激基因，并介导抗病毒反应。然而，STAT3 的作用仍有待阐明。在这里，我们综述了 STAT3 对抑制 IFN-I 反应的多种作用，包括阻断 IFN-I 信号、下调 ISGF3 成分的表达以及拮抗 ISGF3 的转录活性。最后，我们讨论了 STAT3 抑制活性的进化以及 STAT3 抑制剂在宿主防御病毒感染和 IFN-I 相关疾病中的治疗潜力。
Zotero 插件