经动脉化疗栓塞联合射频或微波消融治疗肝细胞癌：综述
Transcatheter arterial chemoembolization combined with radiofrequency or microwave ablation for hepatocellular carcinoma: a review.
作者信息
Galanakis Nikolaos, Kehagias Elias, Matthaiou Nikolas, Samonakis Dimitrios, Tsetis Dimitrios
机构信息
Interventional Radiology Unit, Department of Radiology, University Hospital of Heraklion, Faculty of Medicine, University of Crete, Heraklion, P.C. 71110, Greece.
Department of Gastroenterology, University Hospital of Heraklion, Faculty of Medicine, University of Crete, Heraklion, P.C. 71110, Greece.
出版信息
Hepat Oncol. 2018 Sep 28;5(2):HEP07. doi: 10.2217/hep-2018-0001. eCollection 2018 Apr.
Abstract
Hepatocellular carcinoma (HCC) is the sixth most common type of malignancy. Several therapies are available for HCC and are determined by stage of presentation, patient clinical status and liver function. Local-regional treatment options, including transcatheter arterial chemoembolization, radiofrequency ablation or microwave ablation, are safe and effective for HCC but are accompanied by limitations. The synergistic effects of combined transcatheter arterial chemoembolization and radiofrequency ablation/microwave ablation may overcome these limitations and improve the therapeutic outcome. The purpose of this article is to review the current literature on these combined therapies and examine their efficacy, safety and influence on the overall and recurrence-free survival in patients with HCC.
摘要
肝细胞癌（HCC）是第六大常见恶性肿瘤类型。HCC有多种治疗方法，具体取决于疾病分期、患者临床状况和肝功能。局部区域治疗方案，包括经动脉化疗栓塞、射频消融或微波消融，对HCC安全有效，但也存在局限性。经动脉化疗栓塞与射频消融/微波消融联合应用的协同效应可能克服这些局限性并改善治疗效果。本文旨在综述有关这些联合治疗的当前文献，并探讨其对HCC患者的疗效、安全性以及对总生存期和无复发生存期的影响。
相似文献
1
Transcatheter arterial chemoembolization combined with radiofrequency or microwave ablation for hepatocellular carcinoma: a review.经动脉化疗栓塞联合射频或微波消融治疗肝细胞癌：综述
Hepat Oncol. 2018 Sep 28;5(2):HEP07. doi: 10.2217/hep-2018-0001. eCollection 2018 Apr.
2
Comparison of combination therapies in the management of hepatocellular carcinoma: transarterial chemoembolization with radiofrequency ablation versus microwave ablation.肝细胞癌治疗中联合疗法的比较：经动脉化疗栓塞联合射频消融与微波消融
J Vasc Interv Radiol. 2015 Mar;26(3):330-41. doi: 10.1016/j.jvir.2014.10.047. Epub 2014 Dec 18.
3
Comparison of single-session transarterial chemoembolization combined with microwave ablation or radiofrequency ablation in the treatment of hepatocellular carcinoma: a randomized-controlled study.单疗程经动脉化疗栓塞联合微波消融或射频消融治疗肝细胞癌的比较：一项随机对照研究
Eur J Gastroenterol Hepatol. 2016 Oct;28(10):1198-203. doi: 10.1097/MEG.0000000000000688.
4
Transcatheter arterial chemoembolization combined with radiofrequency ablation delays tumor progression and prolongs overall survival in patients with intermediate (BCLC B) hepatocellular carcinoma.经动脉化疗栓塞联合射频消融可延缓中期（巴塞罗那临床肝癌分期B期）肝细胞癌患者的肿瘤进展并延长总生存期。
BMC Cancer. 2014 Nov 19;14:849. doi: 10.1186/1471-2407-14-849.
5
Transcatheter arterial chemoembolization alone or combined with ablation for recurrent intermediate-stage hepatocellular carcinoma: a propensity score matching study.单纯经导管动脉化疗栓塞术或联合消融治疗复发性中期肝细胞癌: 一项倾向评分匹配研究。
J Cancer Res Clin Oncol. 2020 Oct;146(10):2669-2680. doi: 10.1007/s00432-020-03254-2. Epub 2020 May 25.
6
Long-term outcome of transcatheter arterial chemoembolization after radiofrequency ablation as a combined therapy for Chinese patients with hepatocellular carcinoma.经导管动脉化疗栓塞术联合射频消融术治疗中国肝细胞癌患者的长期疗效
Curr Med Res Opin. 2015 Aug;31(8):1553-60. doi: 10.1185/03007995.2015.1058249. Epub 2015 Jul 9.
7
8
Efficacy and Safety of Radiofrequency Ablation Combined with Transcatheter Arterial Chemoembolization for Hepatocellular Carcinomas Compared with Radiofrequency Ablation Alone: A Time-to-Event Meta-Analysis.与单纯射频消融相比，射频消融联合经动脉化疗栓塞治疗肝细胞癌的疗效和安全性：一项事件时间的Meta分析
Korean J Radiol. 2016 Jan-Feb;17(1):93-102. doi: 10.3348/kjr.2016.17.1.93. Epub 2016 Jan 6.
9
Efficacy of combination therapy with transcatheter arterial chemoembolization and radiofrequency ablation for intermediate-stage hepatocellular carcinoma.经动脉化疗栓塞术与射频消融术联合治疗中期肝细胞癌的疗效
Scand J Gastroenterol. 2018 Dec;53(12):1575-1583. doi: 10.1080/00365521.2018.1548645. Epub 2018 Dec 21.
10
Small hepatocellular carcinoma: is radiofrequency ablation combined with transcatheter arterial chemoembolization more effective than radiofrequency ablation alone for treatment?小肝细胞癌：射频消融联合经动脉化疗栓塞术治疗是否比单纯射频消融更有效？
Radiology. 2009 Sep;252(3):905-13. doi: 10.1148/radiol.2523081676. Epub 2009 Jun 30.
引用本文的文献
1
Recent Advances in Ablative Therapies for HCC.肝癌消融治疗的最新进展
J Clin Exp Hepatol. 2025 Sep-Oct;15(5):102592. doi: 10.1016/j.jceh.2025.102592. Epub 2025 May 17.
2
Meta-analysis of transarterial chemoembolization combined with cryoablation transarterial chemoembolization alone for ≥ 5 cm hepatocellular carcinoma.经动脉化疗栓塞联合冷冻消融与单纯经动脉化疗栓塞治疗直径≥5厘米肝细胞癌的荟萃分析。
World J Gastrointest Oncol. 2024 Jun 15;16(6):2793-2803. doi: 10.4251/wjgo.v16.i6.2793.
3
In Vivo Thermal Ablation of Deep Intrahepatic Targets Using a Super-Convergent MRgHIFU Applicator and a Pseudo-Tumor Model.使用超收敛磁共振引导高强度聚焦超声（MRgHIFU）换能器和假瘤模型对肝内深部靶点进行体内热消融
Cancers (Basel). 2023 Aug 3;15(15):3961. doi: 10.3390/cancers15153961.
4
Recent Advances in Image-Guided Locoregional Therapies for Primary Liver Tumors.原发性肝癌图像引导下局部区域治疗的最新进展
Biology (Basel). 2023 Jul 13;12(7):999. doi: 10.3390/biology12070999.
5
Ablative strategies for recurrent hepatocellular carcinoma.复发性肝细胞癌的消融策略。
World J Hepatol. 2023 Apr 27;15(4):515-524. doi: 10.4254/wjh.v15.i4.515.
6
Bench-to-bedside development of multifunctional flexible embolic agents.多功能柔性栓塞剂的从实验室到临床的开发。
Theranostics. 2023 Apr 1;13(7):2114-2139. doi: 10.7150/thno.80213. eCollection 2023.
7
Salvage locoregional therapies for recurrent hepatocellular carcinoma.挽救性局部区域治疗复发性肝细胞癌。
World J Gastroenterol. 2023 Jan 21;29(3):413-424. doi: 10.3748/wjg.v29.i3.413.
8
Immune checkpoint inhibitor therapy for hepatocellular carcinoma.肝细胞癌的免疫检查点抑制剂疗法
Ann Gastroenterol. 2022 Nov-Dec;35(6):568-576. doi: 10.20524/aog.2022.0746. Epub 2022 Oct 3.
9
Hyperthermia ablation combined with transarterial chemoembolization versus monotherapy for hepatocellular carcinoma: A systematic review and meta-analysis.热消融联合经动脉化疗栓塞与单纯治疗肝癌的疗效比较：系统评价和荟萃分析。
Cancer Med. 2021 Dec;10(23):8432-8450. doi: 10.1002/cam4.4350. Epub 2021 Oct 16.
10
Clinical Study on Effect of Solution Focused Approach on the Complications, Pain, Sleep, and Quality of Life in Patients with Hepatocellular Carcinoma Undergoing TACE.聚焦解决模式对接受肝动脉化疗栓塞术的肝细胞癌患者并发症、疼痛、睡眠及生活质量影响的临床研究
Evid Based Complement Alternat Med. 2021 Sep 15;2021:5068228. doi: 10.1155/2021/5068228. eCollection 2021.
本文引用的文献
1
Clinical study of transcatheter arterial chemoembolization combined with microwave ablation in the treatment of advanced hepatocellular carcinoma.经动脉化疗栓塞联合微波消融治疗晚期肝细胞癌的临床研究
J Cancer Res Ther. 2016 Dec;12(Supplement):C217-C220. doi: 10.4103/0973-1482.200598.
2
Application of radiotherapy for hepatocellular carcinoma in current clinical practice guidelines.放射治疗在当前肝细胞癌临床实践指南中的应用
Radiat Oncol J. 2016 Sep;34(3):160-167. doi: 10.3857/roj.2016.01970. Epub 2016 Sep 28.
3
Microwave ablation of hepatocellular carcinoma as first-line treatment: long term outcomes and prognostic factors in 221 patients.微波消融治疗肝细胞癌作为一线治疗：221 例患者的长期疗效和预后因素。
Sci Rep. 2016 Sep 13;6:32728. doi: 10.1038/srep32728.
4
Combination Therapy of Radiofrequency Ablation and Transarterial Chemoembolization for Unresectable Hepatocellular Carcinoma: A Retrospective Study.射频消融与经动脉化疗栓塞联合治疗不可切除肝细胞癌：一项回顾性研究
Medicine (Baltimore). 2016 May;95(20):e3754. doi: 10.1097/MD.0000000000003754.
5
Treatment of Small Hepatocellular Carcinoma (≤2 cm) in the Caudate Lobe with Sequential Transcatheter Arterial Chemoembolization and Radiofrequency Ablation.尾状叶小肝细胞癌（≤2厘米）的序贯性经动脉化疗栓塞术和射频消融治疗
Cardiovasc Intervent Radiol. 2016 Jul;39(7):1015-22. doi: 10.1007/s00270-016-1314-5. Epub 2016 Mar 14.
6
Efficacy and Safety of Radiofrequency Ablation Combined with Transcatheter Arterial Chemoembolization for Hepatocellular Carcinomas Compared with Radiofrequency Ablation Alone: A Time-to-Event Meta-Analysis.与单纯射频消融相比，射频消融联合经动脉化疗栓塞治疗肝细胞癌的疗效和安全性：一项事件时间的Meta分析
Korean J Radiol. 2016 Jan-Feb;17(1):93-102. doi: 10.3348/kjr.2016.17.1.93. Epub 2016 Jan 6.
7
Radiofrequency ablation plus chemoembolization versus radiofrequency ablation alone for hepatocellular carcinoma: A systematic review and meta-analysis.射频消融联合化疗栓塞与单纯射频消融治疗肝细胞癌的系统评价和荟萃分析。
Clin Res Hepatol Gastroenterol. 2016 Jun;40(3):309-314. doi: 10.1016/j.clinre.2015.07.008. Epub 2015 Oct 1.
8
Guide for diagnosis and treatment of hepatocellular carcinoma.肝细胞癌诊疗指南
World J Hepatol. 2015 Jun 28;7(12):1632-51. doi: 10.4254/wjh.v7.i12.1632.
9
Percutaneous microwave ablation vs radiofrequency ablation in the treatment of hepatocellular carcinoma.经皮微波消融与射频消融治疗肝细胞癌的对比
World J Hepatol. 2015 May 18;7(8):1054-63. doi: 10.4254/wjh.v7.i8.1054.
10
Hepatocellular carcinoma: From diagnosis to treatment.肝细胞癌：从诊断到治疗。
World J Hepatol. 2015 May 18;7(8):1020-9. doi: 10.4254/wjh.v7.i8.1020.
Zotero 插件