Liu Wei, Li Zhixiong, Sun Zhaolin, Xu Yongbin, Wang Shunchun, Hu Yiyang, Peng Jinghua
Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
Data Brief. 2019 Jun 1;25:104087. doi: 10.1016/j.dib.2019.104087. eCollection 2019 Aug.
Fuzheng Huayu (FZHY) capsule is a traditional Chinese medicine composed of six Chinese medicinal herbs Tian et al. [1] and approved by China food and drug administration for liver fibrosis treatment [2], [3] Liu et al., 2009 and Liu et al., 2005. CGA formula consisting of Cordyeps sinensis polysaccharide (CS-PS), gypenosides (G), and amygdalin (A), are derived from FZHY formula. It is necessary to identify the chemical profile of FZHY and CGA formula to describe the mechanisms and the corresponding components of anti-fibrosis. It is showed that FZHY contains adenosine (5.21 mg/g), amygdalin (5.31 mg/g), salvianolic acid b (18.22 mg/g) and deoxyschizandrin (2.62 mg/g), respectively. CS-PS contained 60.5 ± 2.2% total carbohydrate, including 14.17% arabinose, 25.35% glucose and 60.48% galactose. Gypenosides contain 10.34% gypenosides XLIX and 16.58% gypenosides A. These data provide the primary chemical profile of FZHY and CGA formula and an example for components analysis of traditional Chinese medicine.
扶正化瘀(FZHY)胶囊是一种由六种中药材组成的中药,Tian等人[1]报道,该胶囊已获中国食品药品监督管理局批准用于治疗肝纤维化[2,3](Liu等人,2009年和Liu等人,2005年)。由冬虫夏草多糖(CS-PS)、绞股蓝总皂苷(G)和苦杏仁苷(A)组成的CGA配方源自FZHY配方。有必要确定FZHY和CGA配方的化学特征,以描述抗纤维化的机制和相应成分。结果表明,FZHY分别含有腺苷(5.21mg/g)、苦杏仁苷(5.31mg/g)、丹酚酸B(18.22mg/g)和五味子醇甲(2.62mg/g)。CS-PS含有60.5±2.2%的总碳水化合物,其中包括14.17%的阿拉伯糖、25.35%的葡萄糖和60.48%的半乳糖。绞股蓝总皂苷含有10.34%的绞股蓝皂苷XLIX和16.58%的绞股蓝皂苷A。这些数据提供了FZHY和CGA配方的初步化学特征,并为中药成分分析提供了一个实例。