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1
Transcriptional regulation of the proC gene of Salmonella typhimurium.鼠伤寒沙门氏菌proC基因的转录调控
J Bacteriol. 1988 May;170(5):2379-82. doi: 10.1128/jb.170.5.2379-2382.1988.
2
Comparison of proC and other housekeeping genes of Pseudomonas aeruginosa with their counterparts in Escherichia coli.铜绿假单胞菌的proC基因及其他管家基因与大肠杆菌中对应基因的比较。
Gene. 1990 Jan 31;86(1):107-11. doi: 10.1016/0378-1119(90)90121-7.
3
Regulation of proline utilization in Salmonella typhimurium: characterization of put::Mu d(Ap, lac) operon fusions.鼠伤寒沙门氏菌中脯氨酸利用的调控：put::Mu d(Ap, lac)操纵子融合的特性分析
J Bacteriol. 1983 May;154(2):561-8. doi: 10.1128/jb.154.2.561-568.1983.
4
Purification of the putA gene product. A bifunctional membrane-bound protein from Salmonella typhimurium responsible for the two-step oxidation of proline to glutamate.putA基因产物的纯化。一种来自鼠伤寒沙门氏菌的双功能膜结合蛋白，负责脯氨酸两步氧化为谷氨酸。
J Biol Chem. 1981 Sep 25;256(18):9755-61.
5
Complementation of an Escherichia coli proC mutation by a gene cloned from Treponema pallidum.用从梅毒螺旋体克隆的基因对大肠杆菌proC突变进行互补。
J Bacteriol. 1990 Jun;172(6):2996-3002. doi: 10.1128/jb.172.6.2996-3002.1990.
6
Escherichia coli delta 1-pyrroline-5-carboxylate reductase: gene sequence, protein overproduction and purification.大肠杆菌δ1-吡咯啉-5-羧酸还原酶：基因序列、蛋白质过量表达及纯化
Nucleic Acids Res. 1982 Dec 11;10(23):7701-14. doi: 10.1093/nar/10.23.7701.
7
Proline biosynthesis in Saccharomyces cerevisiae: analysis of the PRO3 gene, which encodes delta 1-pyrroline-5-carboxylate reductase.酿酒酵母中的脯氨酸生物合成：编码δ1-吡咯啉-5-羧酸还原酶的PRO3基因分析
J Bacteriol. 1992 Jun;174(11):3782-8. doi: 10.1128/jb.174.11.3782-3788.1992.
8
Enzymatic properties of the purified putA protein from Salmonella typhimurium.鼠伤寒沙门氏菌纯化的PutA蛋白的酶学性质。
J Biol Chem. 1981 Sep 25;256(18):9762-6.
9
Regulation of proline utilization in Salmonella typhimurium: a membrane-associated dehydrogenase binds DNA in vitro.鼠伤寒沙门氏菌中脯氨酸利用的调控：一种与膜相关的脱氢酶在体外与DNA结合。
J Bacteriol. 1991 Jan;173(1):211-9. doi: 10.1128/jb.173.1.211-219.1991.
10
DNA sequence of the putA gene from Salmonella typhimurium: a bifunctional membrane-associated dehydrogenase that binds DNA.鼠伤寒沙门氏菌putA基因的DNA序列：一种与DNA结合的双功能膜相关脱氢酶。
Nucleic Acids Res. 1993 Apr 11;21(7):1676. doi: 10.1093/nar/21.7.1676.

引用本文的文献

1
Bacterial osmoprotectants-a way to survive in saline conditions and potential crop allies.细菌渗透保护剂——一种在盐渍条件下生存的方式及潜在的作物盟友。
FEMS Microbiol Rev. 2025 Jan 14;49. doi: 10.1093/femsre/fuaf020.
2
Regulation of cytoplasmic proline levels in Salmonella typhimurium: effect of osmotic stress on synthesis, degradation, and cellular retention of proline.鼠伤寒沙门氏菌胞质脯氨酸水平的调节：渗透胁迫对脯氨酸合成、降解及细胞内潴留的影响。
J Bacteriol. 1988 May;170(5):2374-8. doi: 10.1128/jb.170.5.2374-2378.1988.
3
Linkage map of Salmonella typhimurium, edition VII.鼠伤寒沙门氏菌连锁图谱，第七版。
Microbiol Rev. 1988 Dec;52(4):485-532. doi: 10.1128/mr.52.4.485-532.1988.
4
Physiological and genetic responses of bacteria to osmotic stress.细菌对渗透胁迫的生理和遗传反应。
Microbiol Rev. 1989 Mar;53(1):121-47. doi: 10.1128/mr.53.1.121-147.1989.
5
Proline biosynthesis in Saccharomyces cerevisiae: analysis of the PRO3 gene, which encodes delta 1-pyrroline-5-carboxylate reductase.酿酒酵母中的脯氨酸生物合成：编码δ1-吡咯啉-5-羧酸还原酶的PRO3基因分析
J Bacteriol. 1992 Jun;174(11):3782-8. doi: 10.1128/jb.174.11.3782-3788.1992.

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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[Reversible specific concentration of amino acids in Escherichia coli].[大肠杆菌中氨基酸的可逆特异性浓度]
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A third L-proline permease in Salmonella typhimurium which functions in media of elevated osmotic strength.鼠伤寒沙门氏菌中的第三种L-脯氨酸通透酶，其在高渗透压强度的培养基中发挥作用。
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Conditionally transposition-defective derivative of Mu d1(Amp Lac).Mu d1（Amp Lac）的条件性转座缺陷衍生物
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Genetic analysis of the proBA genes of Salmonella typhimurium: physical and genetic analyses of the cloned proB+ A+ genes of Escherichia coli and of a mutant allele that confers proline overproduction and enhanced osmotolerance.鼠伤寒沙门氏菌proBA基因的遗传分析：大肠杆菌克隆的proB⁺A⁺基因及赋予脯氨酸过量产生和增强渗透压耐受性的突变等位基因的物理和遗传分析。
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Linkage map of Salmonella typhimurium, Edition VI.鼠伤寒沙门氏菌连锁图谱，第六版。
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Escherichia coli delta 1-pyrroline-5-carboxylate reductase: gene sequence, protein overproduction and purification.大肠杆菌δ1-吡咯啉-5-羧酸还原酶：基因序列、蛋白质过量表达及纯化
Nucleic Acids Res. 1982 Dec 11;10(23):7701-14. doi: 10.1093/nar/10.23.7701.
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The gene-enzyme relationships of proline biosynthesis in Escherichia coli.大肠杆菌中脯氨酸生物合成的基因-酶关系
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New spectrophotometric method for the determination of proline in tissue hydrolyzates.测定组织水解产物中脯氨酸的新分光光度法。
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鼠伤寒沙门氏菌proC基因的转录调控

Transcriptional regulation of the proC gene of Salmonella typhimurium.

作者信息

Brady R A, Csonka L N

机构信息

Department of Biological Sciences, Purdue University, West Lafayette, Indiana 47907.

出版信息

J Bacteriol. 1988 May;170(5):2379-82. doi: 10.1128/jb.170.5.2379-2382.1988.

DOI:10.1128/jb.170.5.2379-2382.1988
PMID:3129409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC211133/
Abstract

We found that the expression of beta-galactosidase in Salmonella typhimurium strains carrying proC-lacZ fusions was neither repressed by excess proline nor derepressed by proline limitation. Except for a three- to fourfold decrease in the beta-galactosidase specific activity under conditions causing a severely reduced growth rate, the expression of the proC-lacZ fusions was nearly invariant under a variety of culture conditions. Thus, the proC gene is unlike most other amino acid biosynthetic genes in that its expression is nearly constitutive.

摘要

我们发现，携带proC-lacZ融合基因的鼠伤寒沙门氏菌菌株中β-半乳糖苷酶的表达既不会因脯氨酸过量而受到抑制，也不会因脯氨酸限制而解除抑制。除了在导致生长速率严重降低的条件下β-半乳糖苷酶比活性下降三到四倍外，proC-lacZ融合基因的表达在各种培养条件下几乎保持不变。因此，proC基因与大多数其他氨基酸生物合成基因不同，其表达几乎是组成型的。