Lim Soo, Min Se Hee, Lee Ji Hyun, Kim Lee Kyung, Lee Dong-Hwa, Lee Jie-Eun, Kim Kyoung Min, Lee Sunmi, Park Kyoung-Chan, Lee Yun Jong
Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
J Obes Metab Syndr. 2019 Jun;28(2):118-128. doi: 10.7570/jomes.2019.28.2.118. Epub 2019 Jun 30.
The prevalence of metabolic syndrome is increasing in Korea, particularly among young adults. This trend will increase the incidence of cardiovascular and metabolic diseases in the future. Therefore, it is imperative to detect and prevent metabolic abnormalities early in life. Here, we established a hospital-based biobank cohort to identify the most prevalent dysmetabolic phenotype. The aim of this report was to inform other researchers of our protocol and to share our data for future collaboration.
The baseline examination comprised health-related questionnaires, anthropometric and handgrip strength measurements, bioelectrical impedance analysis of body composition, and nutritional assessment. Relevant biochemical parameters were measured, and oral glucose tolerance tests were performed. Metabolic syndrome was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria with Asian waist circumference criteria.
From a total of about 3,000 employees aged 20 to 59 years working at Seoul National University Bundang Hospital, 1,017 were enrolled from 2015 to 2016. The mean age was 34.5±8.4 years for men (n=311, 30.6%) and 30.9±8.5 years for women (n=706, 69.4%). The overall prevalence of metabolic syndrome was 7.6% (17.7% in men and 3.1% in women). Among the five components of metabolic syndrome, high blood pressure was the most prevalent in both men (51.4%) and women (13.8%).
Although further follow-up data are needed, we expect that more adverse cardiovascular events may occur in men than in women. This hospital-based cohort will serve as the foundation for a comprehensive evaluation of metabolic syndrome and future cardiometabolic disease risk in middle-aged Koreans.
韩国代谢综合征的患病率正在上升，尤其是在年轻人中。这一趋势将增加未来心血管和代谢疾病的发病率。因此，必须在生命早期检测和预防代谢异常。在此，我们建立了一个基于医院的生物样本库队列，以确定最普遍的代谢异常表型。本报告的目的是向其他研究人员介绍我们的方案，并分享我们的数据以供未来合作。
基线检查包括健康相关问卷、人体测量和握力测量、身体成分生物电阻抗分析以及营养评估。测量相关生化参数，并进行口服葡萄糖耐量试验。代谢综合征根据美国国家胆固醇教育计划成人治疗小组第三次报告的标准以及亚洲腰围标准进行定义。
在首尔国立大学盆唐医院工作的总共约3000名20至59岁的员工中，2015年至2016年招募了1017人。男性（n = 311，30.6%）的平均年龄为34.5±8.4岁，女性（n = 706，69.4%）的平均年龄为30.9±8.5岁。代谢综合征的总体患病率为7.6%（男性为17.7%，女性为3.1%）。在代谢综合征的五个组成部分中，高血压在男性（51.4%）和女性（13.8%）中最为普遍。
尽管需要进一步的随访数据，但我们预计男性可能比女性发生更多不良心血管事件。这个基于医院的队列将作为全面评估韩国中年人代谢综合征和未来心脏代谢疾病风险的基础。
