Rosskamp R, Issa S, Burmeister W
Department of Pediatrics, University of Bonn, FRG.
J Endocrinol Invest. 1988 Jan;11(1):27-30. doi: 10.1007/BF03350090.
Several reports claim that thyroid hormones and growth hormone participate in the regulation of vitamin D synthesis. We investigated whether there was a direct effect of their releasing hormones on vitamin D metabolism. TRH (7 micrograms/kg) was injected iv in 8 children with euthyroid diffuse goiter and GHRF (1 microgram/kg) in 10 short normal children. TRH injection induced significant TSH elevations but no changes in serum vitamin D metabolites, calcium and phosphorus. GHRF administration resulted in marked growth hormone elevations without alterations in the serum vitamin D metabolites, calcium and phosphorus. These results indicate no direct effect of TRH or GHRF itself on vitamin D metabolism, as well as a lack of very short term effect of growth hormone and TSH.
几份报告称甲状腺激素和生长激素参与维生素D合成的调节。我们研究了它们的释放激素对维生素D代谢是否有直接影响。对8名患有甲状腺功能正常的弥漫性甲状腺肿的儿童静脉注射促甲状腺激素释放激素（TRH，7微克/千克），对10名身材矮小但正常的儿童静脉注射生长激素释放因子（GHRF，1微克/千克）。注射TRH可使促甲状腺激素显著升高，但血清维生素D代谢物、钙和磷无变化。给予GHRF导致生长激素显著升高，而血清维生素D代谢物、钙和磷无改变。这些结果表明TRH或GHRF本身对维生素D代谢无直接影响，同时生长激素和促甲状腺激素也缺乏非常短期的影响。
