Röjdmark S, Andersson D E, Edström E, Lamminpää K
Horm Metab Res. 1983 Jun;15(6):290-3. doi: 10.1055/s-2007-1018698.
The influence of iv administration of 0.2 mg thyrotropin-releasing hormone (TRH) on serum calcium was examined in 20 subjects divided into three different groups: one, comprising patients with primary hypothyroidism (A), another, containing euthyroid patients with various diseases (B), and a third, including healthy volunteers (C). Ninety min after the TRH injection total serum calcium (T-Ca) had fallen by 0.19 +/- 0.03 mmol/l in group A (p less than 0.01), by 0.10 +/- 0.02 mmol/l in group B (p less than 0.01), and by 0.08 +/- 0.02 mmol/l in group C (p less than 0.02). Ionized serum calcium (I-Ca) fell in parallel with T-Ca in group A and B. In contrast, serum magnesium was unaffected in all groups. Neither the renal excretion of calcium nor the serum concentration of parathyroid hormone, glucagon or calcitonin changed significantly in response to TRH. These results indicate that TRH has a slight hypocalcemic effect in man which is not caused by plasma dilution, direct influence on the kidneys, or TRH effects on the major calcium regulating hormones. Whether TRH per se, or an increased serum TSH level, induces calcium to leave the vascular space remains to be elucidated.
在20名受试者中研究了静脉注射0.2毫克促甲状腺激素释放激素（TRH）对血清钙的影响，这些受试者被分为三组：一组是原发性甲状腺功能减退患者（A组），另一组是患有各种疾病的甲状腺功能正常患者（B组），第三组是健康志愿者（C组）。注射TRH后90分钟，A组血清总钙（T-Ca）下降了0.19±0.03毫摩尔/升（p<0.01），B组下降了0.10±0.02毫摩尔/升（p<0.01），C组下降了0.08±0.02毫摩尔/升（p<0.02）。A组和B组中，离子化血清钙（I-Ca）与T-Ca平行下降。相比之下，所有组的血清镁均未受影响。TRH注射后，钙的肾排泄以及甲状旁腺激素、胰高血糖素或降钙素的血清浓度均未发生显著变化。这些结果表明，TRH在人体中有轻微的降钙作用，这不是由血浆稀释、对肾脏的直接影响或TRH对主要钙调节激素的作用引起的。TRH本身或血清促甲状腺激素水平升高是否会促使钙离开血管腔仍有待阐明。
