Department of Nephrology, Hui Ya Hospital of the First Affiliated Hospital, Sun Yat-Sen University, HuiZhou, China.
Department of Critical Care Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China.
Nutr Cancer. 2020;72(3):377-385. doi: 10.1080/01635581.2019.1637909. Epub 2019 Jul 11.
To explore the potential relationship between dairy product consumption and bladder cancer risk, we retrieved eligible studies published up to March 15, 2018, via online database search and manual review of the selected articles. Summary relative risk (RR) estimates were calculated using random-effects models based on high to low intake values. Inter-study heterogeneity was explored using stratified analyses of study design, geographic region, or whether studies adjusted for the confounders age, sex, body mass index, smoking, and education level. We extracted data from 16 studies on milk (5,193 subjects) and 10 studies on dairy products (20,434 subjects). The total study population included 220,952 individuals. Dairy product intake and bladder cancer risk were significantly associated, and milk intake and bladder cancer risk more so. Stratified analysis revealed that the trend was more pronounced in case-control studies, and in studies with impact factor <3 and in Asia. The relationship was confirmed after adjusting for sex and Newcastle-Ottawa Scale score of 7 and 8. Our study shows an inverse association between milk consumption and bladder cancer risk.
为了探究乳制品消费与膀胱癌风险之间的潜在关系，我们通过在线数据库检索和对入选文献的手工查阅，检索并获取了截至 2018 年 3 月 15 日发表的合格研究。基于高至低摄入量值，我们采用随机效应模型计算了汇总相对风险（RR）估计值。我们通过研究设计、地理区域或是否调整了年龄、性别、体重指数、吸烟和教育水平等混杂因素的分层分析，探究了研究间的异质性。我们从 16 项关于牛奶（5193 名受试者）和 10 项关于乳制品（20434 名受试者）的研究中提取了数据。总研究人群包括 220952 人。乳制品摄入与膀胱癌风险显著相关，而牛奶摄入与膀胱癌风险的相关性更强。分层分析表明，在病例对照研究以及影响因子<3 和亚洲的研究中，这种趋势更为明显。在调整了性别和纽卡斯尔-渥太华量表评分为 7 和 8 后，这种关系得到了确认。我们的研究表明，牛奶消费与膀胱癌风险呈负相关。
