Department of Emergency, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, China.
Department of Anesthesiology, Zhejiang Provincial People's Hospital, Hangzhou, China.
Nutr Cancer. 2020;72(6):959-967. doi: 10.1080/01635581.2019.1670218. Epub 2019 Oct 4.
To explore a potential relationship between dietary fiber consumption and risk of endometrial cancer (EC), eligible studies published up to 30 June 2018 were retrieved via computer searches and manual review of references. Random-effects models were used to calculate summary relative risk (RR) estimates based on contrasting high- and low-fiber intake values. Sensitivity analysis was conducted, and heterogeneity among study results was explored through stratified analyses by study design, geographic region, Newcastle-Ottawa Scale (NOS) score, impact factor, and adjustment for several confounders (age, body mass index, smoking, energy intake, and education). We extracted data from 16 studies (involving 6,563 cases). There was a significant association between dietary fiber intake and EC (RR = 0.86, 95% confidence interval [CI]: 0.78, 0.93). In stratified analysis, this trend was more pronounced in the case-control studies, and in studies conducted in the Americas and Asia. The relationship was further confirmed after adjusting for education level (RR = 0.74; 95% CI: 0.60, 0.88) and age (RR = 0.70; 95% CI: 0.57, 0.83), and NOS scores of 6 (RR = 0.81; 95% CI: 0.67, 0.95) and 7 (RR = 0.75; 95% CI: 0.62, 0.88). In conclusion, our meta-analysis revealed an inverse association between dietary fiber consumption and EC risk. Further efforts should be made to confirm these findings.
为了探索膳食纤维的摄入与子宫内膜癌（EC）风险之间的潜在关系，我们通过计算机检索和手动查阅参考文献，检索了截至 2018 年 6 月 30 日发表的合格研究。我们采用随机效应模型，根据对比高纤维和低纤维摄入量的值来计算汇总相对风险（RR）估计值。我们进行了敏感性分析，并通过研究设计、地理位置、纽卡斯尔-渥太华量表（NOS）评分、影响因子以及对几个混杂因素（年龄、体重指数、吸烟、能量摄入和教育程度）的调整进行分层分析，探讨了研究结果的异质性。我们从 16 项研究（涉及 6563 例病例）中提取数据。膳食纤维的摄入量与 EC 之间存在显著相关性（RR=0.86，95%置信区间[CI]：0.78，0.93）。在分层分析中，这种趋势在病例对照研究中更为明显，并且在美洲和亚洲进行的研究中更为明显。在调整了教育程度（RR=0.74；95%CI：0.60，0.88）和年龄（RR=0.70；95%CI：0.57，0.83）以及 NOS 评分（RR=0.81；95%CI：0.67，0.95）和 7 分（RR=0.75；95%CI：0.62，0.88）后，这种关系得到了进一步证实。总之，我们的荟萃分析显示膳食纤维的摄入与 EC 风险之间存在负相关关系。应进一步努力证实这些发现。
