Wang Xingyue, Tian Na, He Lili, Yuan Zhixiang, Han Lu
College of Pharmacy, Southwest Minzu University, Chengdu, 610041, People's Republic of China.
Int J Nanomedicine. 2025 May 7;20:5923-5947. doi: 10.2147/IJN.S514928. eCollection 2025.
Over the past two decades, particle-stabilized Pickering emulsions (PEs) have emerged as a versatile platform in pharmaceutical formulations, demonstrating distinct advantages over surfactant-based systems through enhanced stability, reduced toxicity, and tunable interfacial properties. These systems exhibit unique drug delivery potential through their precisely controllable architecture, particularly in achieving spatiotemporal drug release patterns, tissue-specific targeting, and enhanced therapeutic payload encapsulation. In this review, the characteristics of PEs are first detailed, followed by an introduction to the main preparation methods and the key parameters for controlling the type, droplet size, and stability of PEs. The third section categorizes and discusses the advantages and disadvantages of various solid particles as emulsifiers. Lastly, emphasis is placed on the application of PEs in the pharmaceutical field, including functionalized designs and various administration routes to enlighten the rational design of PEs for effective drug delivery.
在过去二十年中，颗粒稳定的皮克林乳液（PEs）已成为药物制剂中的一个多功能平台，通过增强稳定性、降低毒性和可调节的界面性质，显示出优于基于表面活性剂的体系的明显优势。这些体系通过其精确可控的结构展现出独特的药物递送潜力，特别是在实现时空药物释放模式、组织特异性靶向和增强治疗性有效载荷包封方面。在本综述中，首先详细阐述了PEs的特性，接着介绍了主要的制备方法以及控制PEs的类型、液滴大小和稳定性的关键参数。第三部分对各种用作乳化剂的固体颗粒的优缺点进行了分类和讨论。最后，重点介绍了PEs在药物领域的应用，包括功能化设计和各种给药途径，以启发合理设计PEs用于有效的药物递送。
