Research Center on Aging, Faculty of Medicine and Health Sciences, Department of medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada(1).
Research Center on Aging, Faculty of Medicine and Health Sciences, Department of medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada(1); Laboratoire de bio-ingénierie et de biophysique de l'Université de Sherbrooke, Department of Chemical and Biotechnological Engineering, Université de Sherbrooke, 2500 boul. de l'Université, Sherbrooke, Québec J1K 2R1, Canada.
Matrix Biol. 2019 Nov;84:81-96. doi: 10.1016/j.matbio.2019.07.004. Epub 2019 Jul 8.
Once considered as inert, the extracellular matrix recently revealed to be biologically active. Elastin is one of the most important components of the extracellular matrix. Many vital organs including arteries, lungs and skin contain high amounts of elastin to assure their correct function. Physiologically, the organism contains a determined quantity of elastin from the early development which may remain physiologically constant due to its very long half-life and very low turnover. Taking into consideration the continuously ongoing challenges during life, there is a physiological degradation of elastin into elastin-derived peptides which is accentuated in several disease states such as obstructive pulmonary diseases, atherosclerosis and aortic aneurysm. These elastin-derived peptides have been shown to have various biological effects mediated through their interaction with their cognate receptor called elastin receptor complex eliciting several signal transduction pathways. In this review, we will describe the production and the biological effects of elastin-derived peptides in physiology and pathology.
曾经被认为是惰性的细胞外基质最近被揭示具有生物活性。弹性蛋白是细胞外基质的最重要成分之一。许多重要的器官，包括动脉、肺和皮肤，都含有大量的弹性蛋白以确保其正常功能。在生理上，从早期发育开始，机体就含有一定量的弹性蛋白，由于其半衰期非常长且周转率非常低，因此可能保持生理上的恒定。考虑到在生命过程中持续存在的挑战，弹性蛋白会发生生理降解，形成弹性蛋白衍生肽，在几种疾病状态下，如阻塞性肺疾病、动脉粥样硬化和主动脉瘤，这种降解会加剧。已经证明这些弹性蛋白衍生肽通过与它们的同源受体（称为弹性蛋白受体复合物）相互作用，介导多种生物学效应，从而引发多种信号转导途径。在这篇综述中，我们将描述弹性蛋白衍生肽在生理和病理条件下的产生和生物学效应。
