Meddling with myosin's mechanobiology in cancer.
作者信息
Surcel Alexandra, Robinson Douglas N
机构信息
Department of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD 21205;
Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205.
出版信息
Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15322-15323. doi: 10.1073/pnas.1909995116. Epub 2019 Jul 11.
Abstract
摘要
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本文引用的文献
1
Myosin IIA suppresses glioblastoma development in a mechanically sensitive manner.肌球蛋白 IIA 通过机械敏感性抑制胶质母细胞瘤的发展。
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2
Mechanics and Actomyosin-Dependent Survival/Chemoresistance of Suspended Tumor Cells in Shear Flow.悬浮肿瘤细胞在切变流中依赖于力学和肌球蛋白的存活/化疗耐药性。
Biophys J. 2019 May 21;116(10):1803-1814. doi: 10.1016/j.bpj.2019.04.011. Epub 2019 Apr 19.
3
Nonmuscle myosin IIA and IIB differentially modulate migration and alter gene expression in primary mouse tumorigenic cells.非肌肉肌球蛋白 IIA 和 IIB 可调节原发性小鼠肿瘤细胞的迁移并改变其基因表达。
Mol Biol Cell. 2019 Jun 1;30(12):1463-1476. doi: 10.1091/mbc.E18-12-0790. Epub 2019 Apr 17.
4
Mechanochemical Signaling Directs Cell-Shape Change.机械化学信号传导指导细胞形态变化。
Biophys J. 2017 Jan 24;112(2):207-214. doi: 10.1016/j.bpj.2016.12.015.
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Yes-associated protein impacts adherens junction assembly through regulating actin cytoskeleton organization.Yes相关蛋白通过调节肌动蛋白细胞骨架组织来影响黏着连接组装。
Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1;311(3):G396-411. doi: 10.1152/ajpgi.00027.2016. Epub 2016 May 26.
6
Conditional deletion of nonmuscle myosin II-A in mouse tongue epithelium results in squamous cell carcinoma.小鼠舌上皮中非肌肉肌球蛋白II-A的条件性缺失会导致鳞状细胞癌。
Sci Rep. 2015 Sep 15;5:14068. doi: 10.1038/srep14068.
7
Direct in vivo RNAi screen unveils myosin IIa as a tumor suppressor of squamous cell carcinomas.直接体内 RNAi 筛选揭示肌球蛋白 IIa 是鳞状细胞癌的肿瘤抑制因子。
Science. 2014 Jan 17;343(6168):309-13. doi: 10.1126/science.1248627.
8
Deconvolution of the cellular force-generating subsystems that govern cytokinesis furrow ingression.解析控制胞质分裂沟内陷的细胞力产生子系统。
PLoS Comput Biol. 2012;8(4):e1002467. doi: 10.1371/journal.pcbi.1002467. Epub 2012 Apr 26.
9
Direct inhibition of myosin II effectively blocks glioma invasion in the presence of multiple motogens.在多种趋化因子存在的情况下，肌球蛋白 II 的直接抑制可有效阻止神经胶质瘤的侵袭。
Mol Biol Cell. 2012 Feb;23(4):533-42. doi: 10.1091/mbc.E11-01-0039. Epub 2012 Jan 4.
10
Nanomechanical analysis of cells from cancer patients.癌症患者细胞的纳米力学分析。
Nat Nanotechnol. 2007 Dec;2(12):780-3. doi: 10.1038/nnano.2007.388. Epub 2007 Dec 2.
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