Nutrition Research Laboratory, Department of Human Nutrition, Warsaw University of Life Sciences - SGGW, Warsaw, Poland.
Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Heart. 2019 Dec;105(24):1876-1883. doi: 10.1136/heartjnl-2019-315031. Epub 2019 Jul 11.
The relationship between dietary patterns and development of abdominal aortic aneurysm (AAA) is not well understood. Thus, we prospectively evaluated the association between the anti-inflammatory potential of diet and risk of AAA.
The study population included the Cohort of Swedish Men (45 072 men) and the Swedish Mammography Cohort (36 633 women), aged 45-83 years at baseline. The anti-inflammatory potential of diet was estimated using Anti-inflammatory Diet Index (AIDI) based on 11 foods with anti-inflammatory potential and 5 with proinflammatory potential (maximum 16 points) that was validated againsthigh sensitivity C reactive protein (hsCRP). Cox proportional hazard regression models were used to estimate HRs and 95% CIs. During the 14.9 years of follow-up (1 217 263 person-years), 1528 AAA cases (277 (18%) ruptured, 1251 non-ruptured) were ascertained via the Swedish Inpatient Register, the National Cause of Death Register and the Register for Vascular Surgery (Swedvasc).
We observed an inverse association between the AIDI and AAA risk in women and men; HRs between extreme quartiles of the AIDI (≥8 vs ≤5 points) were 0.55 (95% CI 0.36 to 0.83) in women and 0.81 (95% CI 0.68 to 0.98) in men. The AIDI was inversely associated with both ruptured and non-ruptured AAA incidence; the HR of participants in the highest quartile of AIDI compared with those in the lowest quartile was 0.61 (95% CI 0.41 to 0.90) for ruptured AAA and 0.79 (95% CI 0.65 to 0.95) for non-ruptured AAA.
Adherence to diet with a high anti-inflammatory potential was associated with a reduced AAA risk, an association that was even more pronounced for AAA rupture.
饮食模式与腹主动脉瘤（AAA）发展之间的关系尚未明确。因此，我们前瞻性评估了饮食抗炎潜力与 AAA 风险之间的关联。
研究人群包括瑞典男性队列（45072 名男性）和瑞典乳腺 X 线摄影队列（36633 名女性），基线时年龄为 45-83 岁。采用抗炎饮食指数（AIDI）来评估饮食的抗炎潜力，该指数基于具有抗炎潜力的 11 种食物和具有促炎潜力的 5 种食物（最高 16 分），并通过高敏 C 反应蛋白（hsCRP）进行验证。采用 Cox 比例风险回归模型估计 HR 和 95%CI。在 14.9 年的随访期间（1217263 人年），通过瑞典住院患者登记处、国家死因登记处和血管外科登记处（Swedvasc）确定了 1528 例 AAA 病例（277 例破裂，1251 例未破裂）。
我们观察到 AIDI 与女性和男性的 AAA 风险之间呈负相关；AIDI 极值四分位数（≥8 分与≤5 分）之间的 HR 分别为女性 0.55（95%CI 0.36 至 0.83）和男性 0.81（95%CI 0.68 至 0.98）。AIDI 与破裂性和非破裂性 AAA 发生率均呈负相关；与 AIDI 最低四分位数相比，最高四分位数参与者的破裂性 AAA 的 HR 为 0.61（95%CI 0.41 至 0.90），非破裂性 AAA 的 HR 为 0.79（95%CI 0.65 至 0.95）。
饮食抗炎潜力高与 AAA 风险降低相关，对于 AAA 破裂，这种相关性更为明显。
