Department of Neurobiology, The University of Chicago, Chicago, IL 60637, USA.
Science. 2019 Jul 12;365(6449):180-185. doi: 10.1126/science.aaw8347.
Posterior parietal cortex (PPC) activity correlates with monkeys' decisions during visual discrimination and categorization tasks. However, recent work has questioned whether decision-correlated PPC activity plays a causal role in such decisions. That study focused on PPC's contribution to motor aspects of decisions (deciding where to move), but not sensory evaluation aspects (deciding what you are looking at). We employed reversible inactivation to compare PPC's contributions to motor and sensory aspects of decisions. Inactivation affected both aspects of behavior, but preferentially impaired decisions when visual stimuli, rather than motor response targets, were in the inactivated visual field. This demonstrates a causal role for PPC in decision-making, with preferential involvement in evaluating attended task-relevant sensory stimuli compared with motor planning.
顶叶后皮质(PPC)的活动与猴子在视觉辨别和分类任务中的决策相关。然而,最近的研究质疑决策相关的 PPC 活动是否在这些决策中起因果作用。该研究主要关注 PPC 对决策的运动方面(决定移动的位置)的贡献,而不是感觉评估方面(决定看什么)。我们采用可逆失活来比较 PPC 对决策的运动和感觉方面的贡献。失活影响了行为的两个方面,但当视觉刺激而不是运动反应目标处于失活的视野中时,更优先地损害了决策。这证明了 PPC 在决策中的因果作用,与运动计划相比,PPC 更优先地参与评估被关注的与任务相关的感觉刺激。