Ahmed Bashir, Ko Hee-Kyoung, Rüsseler Maria, Smith Jackson E T, Krug Kristine
Department of Physiology Anatomy and Genetics, University of Oxford, Oxford, UK.
Department of Psychology and Clinical Language Sciences, Reading University, Reading, UK.
Commun Biol. 2025 Sep 9;8(1):1337. doi: 10.1038/s42003-025-08596-6.
Primate lateral intraparietal area (LIP) has been directly linked to perceptual categorization and decision-making. However, the intrinsic LIP circuitry that gives rise to the flexible generation of motor responses to sensory instruction remains unclear. Using retrograde tracers, we delineate two distinct operational compartments based on different intrinsic connectivity patterns of dorsal and ventral LIP. These connections form an anatomical loop with a sensory-like, point-to-point projection from ventral to dorsal LIP and an asymmetric, widespread projection in reverse. In neurophysiological recordings, LIP neurons exhibit motor response fields spatially distinct from their sensory receptive field. Different associations of motor response and receptive fields in single neurons tile visual space. Ventral LIP neurons tend to have motor response fields distant from their sensory receptive fields. This circuit provides the neural substrate to generate the dynamic processes for flexible allocation of attention and motor responses in response to salient or instructive visual input across the visual field.
灵长类动物的顶内沟外侧区（LIP）已被直接与感知分类和决策联系起来。然而，导致对感觉指令灵活产生运动反应的内在LIP神经回路仍不清楚。利用逆行示踪剂，我们根据背侧和腹侧LIP不同的内在连接模式描绘出两个不同的功能区。这些连接形成了一个解剖学环路，从腹侧到背侧LIP有类似感觉的点对点投射，反之则有不对称的广泛投射。在神经生理学记录中，LIP神经元表现出在空间上与其感觉感受野不同的运动反应野。单个神经元中运动反应和感受野的不同关联覆盖了视觉空间。腹侧LIP神经元的运动反应野往往远离其感觉感受野。该神经回路为在整个视野中响应显著或指导性视觉输入而灵活分配注意力和运动反应的动态过程提供了神经基础。
