喂养不足作为中早产儿出院障碍。
Inadequate oral feeding as a barrier to discharge in moderately preterm infants.
机构信息
Department of Pediatrics, Duke University, Durham, NC, 27708, USA.
WakeMed Health and Hospitals, Raleigh, NC, 27610, USA.
出版信息
J Perinatol. 2019 Sep;39(9):1219-1228. doi: 10.1038/s41372-019-0422-x. Epub 2019 Jul 11.
OBJECTIVES
The objectives describe the frequency that inadequate oral feeding (IOF) is the reason why moderately preterm (MPT) infants remain hospitalized and its association with neonatal morbidities.
STUDY DESIGN
Prospective study using the NICHD Neonatal Research Network MPT Registry. Multivariable logistic regression was used to describe associations between IOF and continued hospitalization at 36 weeks postmenstrual age (PMA).
RESULT
A total of 6017 MPT infants from 18 centers were included. Three-thousand three-seventy-six (56%) remained hospitalized at 36 weeks PMA, of whom 1262 (37%) remained hospitalized due to IOF. IOF was associated with RDS (OR 2.02, 1.66-2.46), PDA (OR 1.86, 1.37-2.52), sepsis (OR 2.36, 95% 1.48-3.78), NEC (OR 16.14, 7.27-35.90), and BPD (OR 3.65, 2.56-5.21) compared to infants discharged and was associated with medical NEC (OR 2.06, 1.19-3.56) and BPD (OR 0.46, 0.34-0.61) compared to infants remaining hospitalized for an alternative reason.
CONCLUSION
IOF is the most common barrier to discharge in MPT infants, especially among those with neonatal morbidities.
目的
本研究旨在描述喂养不足（IOF）导致中早产儿（MPT）持续住院的频率，并探讨其与新生儿并发症之间的关系。
研究设计
本研究采用前瞻性研究设计，使用 NICHD 新生儿研究网络 MPT 登记处的数据。采用多变量逻辑回归模型来描述 IOF 与 36 孕周校正胎龄（PMA）时持续住院之间的关联。
结果
本研究共纳入了来自 18 个中心的 6017 名 MPT 婴儿。其中 3376 名（56%）婴儿在 36 孕周 PMA 时仍住院，其中 1262 名（37%）因 IOF 而继续住院。IOF 与 RDS（OR 2.02，1.66-2.46）、PDA（OR 1.86，1.37-2.52）、败血症（OR 2.36，95%CI 1.48-3.78）、NEC（OR 16.14，7.27-35.90）和 BPD（OR 3.65，2.56-5.21）有关，与出院婴儿相比，与医源性 NEC（OR 2.06，1.19-3.56）和 BPD（OR 0.46，0.34-0.61）有关。
结论
IOF 是 MPT 婴儿出院的最常见障碍，尤其是在伴有新生儿并发症的婴儿中。
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