Üstündağ Okur Neslihan, Hökenek Nesrin, Okur Mehmet Evren, Ayla Şule, Yoltaş Ayşegül, Siafaka Panoraia I, Cevher Erdal
University of Health Sciences, Faculty of Pharmacy, Department of Pharmaceutical Technology, Istanbul, Turkey.
Istanbul Medipol University, School of Pharmacy, Department of Pharmaceutical Technology, Istanbul, Turkey.
Saudi Pharm J. 2019 Jul;27(5):738-752. doi: 10.1016/j.jsps.2019.04.010. Epub 2019 Apr 20.
In this study, novel adhesive films were prepared for Mupirocin dermal delivery. Natural polymers as chitosan, sodium alginate and carbopol were used for films development to evaluate possible interactions and drug release properties. Solvent evaporation method was used for films preparation. Preliminary studies involved FT-IR spectroscopy and Scanning Electron Microscopy to specify interactions and morphology. Thickness, tensile strength and water uptake in phosphate buffer saline were evaluated whereas release studies were also performed. drug release studies demonstrated that mupirocin release was improved. bioadhesion and permeation studies using Balb-c mice were performed to check the suitability of the films. Antimicrobial ability was evaluated by agar well diffusion tests. Finally, excisional wound model applied to test the wound healing effect and evaluated macroscopic and histopathologically. One formulation was found more effective compared to the market product for wound healing at Balb-c mice.
在本研究中，制备了用于莫匹罗星经皮给药的新型粘附膜。使用壳聚糖、海藻酸钠和卡波姆等天然聚合物来开发薄膜，以评估可能的相互作用和药物释放特性。采用溶剂蒸发法制备薄膜。初步研究涉及傅里叶变换红外光谱和扫描电子显微镜，以确定相互作用和形态。评估了薄膜在磷酸盐缓冲盐水中的厚度、拉伸强度和吸水性，同时也进行了释放研究。药物释放研究表明莫匹罗星的释放得到了改善。使用Balb-c小鼠进行了生物粘附和渗透研究，以检验薄膜的适用性。通过琼脂孔扩散试验评估抗菌能力。最后，应用切除伤口模型来测试伤口愈合效果，并进行宏观和组织病理学评估。发现在Balb-c小鼠伤口愈合方面，一种配方比市售产品更有效。
