Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Department of Obstetric and Gynecology, National Yang-Ming University, Taipei, Taiwan, ROC; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, ROC; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan, ROC.
Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; Department of Obstetric and Gynecology, National Yang-Ming University, Taipei, Taiwan, ROC; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.
J Chin Med Assoc. 2018 Feb;81(2):94-101. doi: 10.1016/j.jcma.2017.11.002. Epub 2017 Nov 21.
Wound healing is an important physiological process to maintain the integrity of skin after trauma, either by accident or by intent procedure. The normal wound healing involves three successive but overlapping phases, including hemostasis/inflammatory phase, proliferative phase, and remodeling phase. Aberration of wound healing, such as excessive wound healing (hypertrophic scar and keloid) or chronic wound (ulcer) impairs the normal physical function. A large number of sophisticated experimental studies have provided insights into wound healing. This article highlights the information after 2010, and the main text includes (i) wound healing; (ii) wound healing in fetus and adult; (iii) prostaglandins and wound healing; (iv) the pathogenesis of excessive wound healing; (v) the epidemiology of excessive wound healing; (vi) in vitro and in vivo studies for excessive wound healing; (vii) stem cell therapy for excessive wound healing; and (viii) the prevention strategy for excessive wound healing.
伤口愈合是一种重要的生理过程，用于在创伤后维持皮肤的完整性，无论是意外还是有意的手术。正常的伤口愈合涉及三个连续但重叠的阶段，包括止血/炎症期、增殖期和重塑期。伤口愈合的异常，如过度的伤口愈合（增生性瘢痕和瘢痕疙瘩）或慢性伤口（溃疡），会损害正常的身体功能。大量复杂的实验研究为伤口愈合提供了深入的了解。本文重点介绍了 2010 年后的信息，主要内容包括（i）伤口愈合；（ii）胎儿和成人的伤口愈合；（iii）前列腺素与伤口愈合；（iv）过度伤口愈合的发病机制；（v）过度伤口愈合的流行病学；（vi）过度伤口愈合的体外和体内研究；（vii）过度伤口愈合的干细胞治疗；以及（viii）过度伤口愈合的预防策略。
