Chen Yanjun, Pinto Alex A, Paulsen Adam J, Schubert Carla R, Hancock Laura M, Klein Barbara E, Klein Ron, Cruickshanks Karen J
Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.
Front Neurol. 2019 Jun 26;10:682. doi: 10.3389/fneur.2019.00682. eCollection 2019.
We conducted a cross-sectional study on 403 participants in the 10-year follow-up examination of the Beaver Dam Offspring Study. The participants included 172 male and 231 female, with age ranging from 33 to 81 years (mean ± SD, 60.7 ± 9.3). The post-illumination pupil response (PIPR) was recorded using binocular infrared pupillometer (Neur-Optics, Inc., Irvine, CA). Cognitive testing consisted of Trail Making Test (TMT) Parts A and B, Rey Auditory Verbal Learning Test (AVLT), Digit Symbol Substitution Test (DSST), and Verbal Fluency Test (VFT) (F, A, and S). Principal component analysis (PCA) was used to calculate an overall cognitive function score. There was a significant reduction in the mean baseline pupil diameter by 0.21 mm for every 5-year increase in age (95% CI: -0.25, -0.17). There was also a significant increase in the PCA cognitive score by 0.20 (linear regression, 95% CI: 0.08, 0.32) for every 0.1 unit increase in the PIPR. The association remained significant after adjusting for age, sex, education, medications, systemic and ocular disease, and short form-12 physical and mental component score. The results of this study demonstrated a modest association between the PIPR and cognitive function, warranting longitudinal studies to evaluate the role of the PIPR in predicting cognitive function in the middle-aged and older adults.
我们对参加比弗代姆后代研究10年随访检查的403名参与者进行了一项横断面研究。参与者包括172名男性和231名女性，年龄在33岁至81岁之间（均值±标准差，60.7±9.3）。使用双目红外瞳孔计（Neur-Optics公司，加利福尼亚州欧文市）记录光照后瞳孔反应（PIPR）。认知测试包括连线测验（TMT）A部分和B部分、雷伊听觉词语学习测验（AVLT）、数字符号替换测验（DSST）和言语流畅性测验（VFT）（F、A和S）。主成分分析（PCA）用于计算总体认知功能评分。年龄每增加5岁，平均基线瞳孔直径显著减少0.21毫米（95%置信区间：-0.25，-0.17）。PIPR每增加0.1单位，PCA认知评分显著增加0.20（线性回归，95%置信区间：0.08，0.32）。在调整年龄、性别、教育程度、药物治疗、全身和眼部疾病以及简明健康调查12项身心成分评分后，该关联仍然显著。本研究结果表明PIPR与认知功能之间存在适度关联，有必要进行纵向研究以评估PIPR在预测中老年认知功能中的作用。
