Garcia-Martin Elena, Bambo Maria P, Marques Marcia L, Satue Maria, Otin Sofia, Larrosa Jose M, Polo Vicente, Pablo Luis E
Ophthalmology Department, Miguel Servet University Hospital, Zaragoza, Spain.
Aragon Institute of Health Research, IIS-Aragon, Zaragoza, Spain.
Acta Ophthalmol. 2016 Sep;94(6):e454-9. doi: 10.1111/aos.12977. Epub 2016 Feb 19.
To evaluate the thickness of the 10 retinal layers of patients with Alzheimer's disease (AD) using a new segmentation technology of the Spectralis optical coherence tomography (OCT) and to determine whether the thickness of specific layers predicts neurodegeneration or AD severity.
Patients with AD (n = 150) and age-matched healthy controls (n = 75) were analysed using the segmentation application prototype to automatically segment all retinal layers in a macular scan. Thicknesses of each layer were compared between patients with AD and controls, and between patients with disease durations of less than or at least 3 years. Associations between retinal layer thicknesses, disease duration and AD severity were evaluated.
Patients with AD had reduced thickness in the retinal nerve fibre, ganglion cell, inner plexiform and outer nuclear layers (p < 0.05). The inner retinal layers were more affected in patients with long disease duration. Ganglion cell and retinal nerve fibre layer thicknesses were inversely correlated with AD duration and severity. Ganglion cell and inner plexiform layers thicknesses were predictive of axonal damage.
The segmentation application revealed ganglion cell and retinal layer atrophy in patients with AD compared with controls, especially in the inner layers of patients with long disease duration. Ganglion cell layer reduction was associated with increased axonal damage and may predict greater disease severity.
使用光谱光学相干断层扫描（OCT）的一种新分割技术评估阿尔茨海默病（AD）患者10个视网膜层的厚度，并确定特定层的厚度是否可预测神经退行性变或AD严重程度。
使用分割应用程序原型对150例AD患者和75例年龄匹配的健康对照进行分析，以自动分割黄斑扫描中的所有视网膜层。比较AD患者与对照组之间以及病程小于或至少3年的患者之间各层的厚度。评估视网膜层厚度、病程和AD严重程度之间的关联。
AD患者的视网膜神经纤维层、神经节细胞层、内网状层和外核层厚度降低（p<0.05）。病程长的患者内视网膜层受影响更大。神经节细胞层和视网膜神经纤维层厚度与AD病程和严重程度呈负相关。神经节细胞层和内网状层厚度可预测轴突损伤。
与对照组相比，分割应用显示AD患者存在神经节细胞层和视网膜层萎缩，尤其是病程长的患者的内层。神经节细胞层减少与轴突损伤增加有关，可能预示疾病严重程度更高。
