基于纸张的认知训练对早期阿尔茨海默病痴呆的影响。
Effect of Paper-Based Cognitive Training in Early Stage of Alzheimer's Dementia.
作者信息
Kang Min Ju, Kim So Min, Han Seo Eun, Bae Ji Hyun, Yu Woo Jin, Park Min Young, Ku Seongsu, Yang YoungSoon
机构信息
Department of Neurology, Veterans Medical Research Institute, Veterans Health Service Medical Center, Seoul, Korea.
Hanam City Public Health Center, Hanam, Korea.
出版信息
Dement Neurocogn Disord. 2019 Jun;18(2):62-68. doi: 10.12779/dnd.2019.18.2.62. Epub 2019 Jul 3.
BACKGROUND AND PURPOSE
Cognitive training refers to a series of standardized tasks with inherent challenges that target specific cognitive domains. Positive outcome of cognitive training in persons with Alzheimer's disease has been reported. In this study, the objective was to design sets of cognitive training program, "Gipum-seo" which is combined cognitive training, consists of different levels of difficulty using predesigned paper-and-pencil exercises. Also, to evaluate the effects of the cognitive training on patients' with early stage of Alzheimer's disease.
METHODS
The subjects for this study were forty participants who were diagnosed with early stage of Alzheimer's dementia. To test the efficacy of paper-based cognitive training programs to cognition, all patients were randomly grouped to either an intervention group (=20) or a control group (=20). The intervention group regularly received 24 sessions of paper-based cognitive training over a 12-week period. Neuropsychological examinations were conducted before and after this training period.
RESULTS
After the 12 weeks, the intervention group showed a significant change in Korean version of the Mini-Mental State Examination (25.90±3.8), compared to the control group (23.7±2.8) (=0.042). The training group also showed a significant improvement in language, attention and executive function, as compared with controls.
CONCLUSIONS
Paper-based cognitive training might have beneficial effects on the general cognitive functions in the early stage of Alzheimer's dementia.
背景与目的
认知训练是指针对特定认知领域的一系列具有内在挑战性的标准化任务。已有报道称认知训练对阿尔茨海默病患者有积极效果。在本研究中，目的是设计一套名为“Gipum-seo”的认知训练方案，该方案将认知训练与使用预先设计的纸笔练习相结合，具有不同难度级别。此外，评估认知训练对早期阿尔茨海默病患者的效果。
方法
本研究的受试者为40名被诊断为早期阿尔茨海默病痴呆的参与者。为测试基于纸笔的认知训练方案对认知的疗效，所有患者被随机分为干预组（=20）和对照组（=20）。干预组在12周内定期接受24次基于纸笔的认知训练。在该训练期前后进行神经心理学检查。
结果
12周后，干预组在韩国版简易精神状态检查表上的得分有显著变化（25.90±3.8），而对照组为（23.7±2.8）（P=0.042）。与对照组相比，训练组在语言、注意力和执行功能方面也有显著改善。
结论
基于纸笔的认知训练可能对早期阿尔茨海默病痴呆患者的一般认知功能有有益影响。
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