人类免疫缺陷病毒相关卡波西肉瘤的最新进展
Recent advances in HIV-associated Kaposi sarcoma.
作者信息
Dalla Pria Alessia, Pinato David J, Bracchi Margherita, Bower Mark
机构信息
Imperial College London, London, UK.
Chelsea and Westminster Hospital, London, UK.
出版信息
F1000Res. 2019 Jun 26;8. doi: 10.12688/f1000research.17401.1. eCollection 2019.
Abstract
Kaposi sarcoma (KS) is a mesenchymal tumour caused by KS-associated herpesvirus and is an AIDS-defining illness. Despite a decline in incidence since the introduction of combination anti-retroviral therapy, KS remains the most common cancer in people living with HIV in sub-Saharan Africa, where it causes significant morbidity and mortality. This review reflects on recent epidemiological data as well as current management, unmet needs and future perspectives in the treatment of HIV-associated KS with particular emphasis on the potential role of immune checkpoint inhibitors.
摘要
卡波西肉瘤（KS）是一种由卡波西肉瘤相关疱疹病毒引起的间充质肿瘤，是一种艾滋病界定疾病。尽管自联合抗逆转录病毒疗法引入以来发病率有所下降，但KS仍然是撒哈拉以南非洲地区艾滋病毒感染者中最常见的癌症，在该地区它会导致严重的发病率和死亡率。本综述回顾了近期的流行病学数据以及目前在治疗艾滋病毒相关KS方面的管理、未满足的需求和未来展望，特别强调了免疫检查点抑制剂的潜在作用。
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