Trașcă S P, Goanță E V, Târtea G C, Ciurea P L
Department of Cardiology, Emergency County Hospital of Craiova, Romania.
Department of Physiology, University of Medicine and Pharmacy of Craiova, Romania.
Curr Health Sci J. 2019 Jan-Mar;45(1):19-27. doi: 10.12865/CHSJ.45.01.02. Epub 2019 Mar 31.
The aim of our study was to identify the cardiovascular risk factors present in patients with left main coronary artery disease (LMCAD), which influenced the progression of these patients in both percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CABG). We performed a clinical observational descriptive study in which, during three years, we followed the evolution of 81 patients who were diagnosed with left main coronary artery disease and who were treated either by interventional revascularization by stent implantation, by surgical revascularization by performing an aortic-coronary bypass. In our study the risk factors according to which the evolution of the patients was observed were represented by diabetes, smoking, age and gender. The primary endpoint was mortality from any cause and other clinical endpoints were the reduction of left ventricular ejection fraction, symptomatic ischemic heart disease manifested by angina pectoris, non-procedural myocardial infarction or need for repeated revascularization. In our study diabetes was the risk factor that negatively influenced the evolution of patients with LMCAD treated either by PCI or by CABG for the most part, followed by smoking, male gender and age over 65 years.
我们研究的目的是确定左主干冠状动脉疾病（LMCAD）患者中存在的心血管危险因素，这些因素在经皮冠状动脉介入治疗（PCI）和冠状动脉旁路移植术（CABG）中均会影响这些患者的病情进展。我们进行了一项临床观察性描述性研究，在三年时间里，跟踪了81例被诊断为左主干冠状动脉疾病的患者的病情发展，这些患者接受了通过支架植入进行的介入性血运重建治疗，或通过实施主动脉-冠状动脉旁路移植术进行的外科血运重建治疗。在我们的研究中，观察患者病情发展所依据的危险因素包括糖尿病、吸烟、年龄和性别。主要终点是任何原因导致的死亡率，其他临床终点包括左心室射血分数降低、以心绞痛表现的有症状缺血性心脏病、非手术相关心肌梗死或再次血运重建的需求。在我们的研究中，糖尿病是对接受PCI或CABG治疗的LMCAD患者病情发展产生负面影响的主要危险因素，其次是吸烟、男性性别和65岁以上年龄。
