Training and Research Hospital, Department of Cardiology, Siirt /Turkey.
Antalya Education and Research Hospital; Department of Emergency Medicine, Antalya /Turkey.
Afr Health Sci. 2022 Jun;22(2):273-285. doi: 10.4314/ahs.v22i2.31.
Nonalcoholic fatty liver disease (NAFLD) has shown to be associated with coronary artery disease (CAD).
The aim of our study was to evaluate the association between the presence and severity of CAD and NAFLD.
The study group consisted of 153 patients who underwent coronary angiographies. Patients were categorized into CAD and non-CAD groups. CAD severity was determined by the number of CAD-involved arteries and the vessel score multiplied by Gensini score, the latter judging CAD severity. Fatty liver was diagnosed by abdominal ultrasonography (USG), with the patients being categorized by the degree of hepatosteatosis, as Grade 0, Grade 1, and Grade 2-3.
Among the whole study population, 47.1% of patients (n=72) were female and 52.9% of patients (n=81) were male. Forty-three patients had normal coronary arteries; 27 patients had non-critical CAD and side branch disease; and 83 patients had clinically significant CAD (stenosis>50%). The rate of CAD and Gensini score were significantly different between Grade 0, 1 and 2-3 hepatosteatosis groups (p<0.05). Patients with CAD had a significantly higher AST level than those without (p< 0.05).
Ultrasonographically detected hepatosteatosis independently predicts the presence and severity of CAD.
非酒精性脂肪性肝病（NAFLD）已被证明与冠状动脉疾病（CAD）有关。
本研究旨在评估 CAD 的存在和严重程度与 NAFLD 之间的关系。
研究组包括 153 名接受冠状动脉造影的患者。患者分为 CAD 组和非 CAD 组。CAD 严重程度通过 CAD 受累动脉的数量和乘以 Gensini 评分的血管评分来确定，后者判断 CAD 的严重程度。通过腹部超声（USG）诊断脂肪肝，根据肝脂肪变性程度将患者分为 0 级、1 级和 2-3 级。
在整个研究人群中，47.1%的患者（n=72）为女性，52.9%的患者（n=81）为男性。43 例患者冠状动脉正常；27 例患者患有非临界 CAD 和侧支病变；83 例患者患有临床显著 CAD（狭窄>50%）。0 级、1 级和 2-3 级肝脂肪变性组的 CAD 和 Gensini 评分的发生率有显著差异（p<0.05）。患有 CAD 的患者的 AST 水平明显高于无 CAD 的患者（p<0.05）。
超声检测到的肝脂肪变性独立预测 CAD 的存在和严重程度。
