Graduate Course of Health and Social Services, Saitama Prefectural University, 820 San-Nomiya, Koshigaya-shi, Saitama, 343-8540, Japan.
Department of Breast Center, St Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan.
Breast Cancer. 2020 Jan;27(1):62-69. doi: 10.1007/s12282-019-00993-0. Epub 2019 Jul 11.
The aim was to clarify subjective symptoms and quality of life (QOL) in breast cancer patients receiving hormone therapy.
After obtaining approval from the research ethics committee, an observational study using a self-administered questionnaire was conducted at outpatient clinical oncology offices in 3 facilities that targeted breast cancer patients under the age of 50 who had been undergoing hormone therapy for less than 1 year. The study examined elements such as the breast cancer patients' basic information, symptoms, pain in daily life, QOL, and depression/anxiety.
There were 214 valid responses. The respondents had an average age of 43.6. Of them, 100% were also treated with Tamoxifen and 30% with LH-RH agonist. There were 75% who were cognizant of side effects. Difficult symptoms that occurred with high frequency were stiff shoulders/back pain, decreased physical strength, hot flashes, and sweating. Over half the respondents were uncertain as to whether the subjective symptoms were side effects. They lost confidence in their physical strength and felt distressed over weight gain. There were 51 with a HADS anxiety score of 8 or higher, and 46 who scored 8 points or higher for depression.
Breast cancer patients undergoing hormone therapy experience a variety of pains, and some also have serious psychological symptoms. Reassessing support systems to examine screening and self-care support is an issue going forward.
本研究旨在阐明接受激素治疗的乳腺癌患者的主观症状和生活质量（QOL）。
本研究为观察性研究，采用问卷调查的方式，在 3 家医疗机构的门诊临床肿瘤诊室中进行，调查对象为年龄小于 50 岁、正在接受激素治疗且治疗时间少于 1 年的乳腺癌患者。研究内容包括乳腺癌患者的基本信息、症状、日常生活中的疼痛、QOL 和抑郁/焦虑等。
共回收 214 份有效问卷。受访者的平均年龄为 43.6 岁，均接受他莫昔芬治疗，30%接受 LH-RH 激动剂治疗。75%的患者知晓药物的副作用。常出现的严重症状为肩部/背部僵硬、体力下降、热潮红和出汗。超过一半的受访者不确定主观症状是否为药物的副作用，对体力下降感到不安，对体重增加感到苦恼。汉密尔顿焦虑量表（HADS）评分 8 分及以上者 51 例，抑郁量表（HADS）评分 8 分及以上者 46 例。
接受激素治疗的乳腺癌患者会经历各种疼痛，部分患者还存在严重的心理症状。今后需要重新评估支持系统，检查筛查和自我护理支持情况。
