Department of Oral Pathology, School of Dentistry, Federal University of Ceara, Rua Monsenhor Furtado, Fortaleza, Ceara, 60430-355, Brazil.
Department of Oral Pathology, School of Dentistry, Federal University of Para, Avenida Augusto Correa, 01, Belem, Para, 66075-110, Brazil.
Head Neck Pathol. 2020 Jun;14(2):497-502. doi: 10.1007/s12105-019-01053-x. Epub 2019 Jul 11.
Central giant cell granuloma (CGCG) is a benign intraosseous lesion of the head and neck with potential for aggressive and locally destructive behaviour. Lesions of the maxilla tend to expand more than those of the mandible due to the thinner cortices and spongy tissue of this location. Surgical removal is the most common treatment; however, it may be disfiguring in aggressive cases, especially for lesions located in the maxilla. Alternative treatments, such as intralesional corticosteroid injections, have been performed with satisfactory results. We report a case of a 12-year-old female patient with a CGCG of the left maxilla that was treated with 40 doses of intralesional triamcinolone acetonide infiltrations combined with alendronate sodium and calcium carbonate. Clinical and imaging follow-up over 12 years demonstrates improvement in the patient's condition.
中央性 giant 细胞肉芽肿（CGCG）是一种良性的头颈部骨内病变，具有侵袭性和局部破坏性的潜在风险。上颌骨的病变往往比下颌骨的病变扩张得更大，因为上颌骨的皮质和海绵组织更薄。手术切除是最常见的治疗方法；然而，在侵袭性病例中，特别是对于位于上颌骨的病变，可能会导致毁容。替代治疗方法，如病灶内皮质类固醇注射，已取得满意的效果。我们报告了一例 12 岁女性患者，左侧上颌骨 CGCG 采用 40 次病灶内曲安奈德丙酮注射联合阿仑膦酸钠和碳酸钙治疗。12 年的临床和影像学随访显示患者病情改善。
