多关节炎患者血清铜蓝蛋白浓度及氧化酶活性
Caeruloplasmin concentration and oxidase activity in polyarthritis.
作者信息
Dixon J S, Greenwood M, Lowe J R
机构信息
Clinical Pharmacology Unit, Royal Bath Hospital, Harrogate, North Yorkshire, UK.
出版信息
Rheumatol Int. 1988;8(1):11-4. doi: 10.1007/BF00541344.
Caeruloplasmin (Cp) concentration and oxidase activity have been shown to be elevated in rheumatoid arthritis (RA) and psoriatic arthritis, but normal in Reiter's syndrome, Behcet's syndrome and juvenile seronegative polyarthritis. Synovial fluid Cp was significantly depressed in comparison with serum Cp in RA. During second-line therapy in RA, Cp concentration and activity fell significantly (P less than 0.001), but the change in Cp did not correlate with plasma viscosity.
在类风湿关节炎（RA）和银屑病关节炎中，血浆铜蓝蛋白（Cp）浓度及氧化酶活性已被证实升高，但在赖特综合征、白塞综合征和青少年血清阴性多关节炎中则正常。与血清Cp相比，RA患者滑液中的Cp显著降低。在RA的二线治疗期间，Cp浓度及活性显著下降（P<0.001），但Cp的变化与血浆黏度并无关联。
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