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比较VivaSight双腔导管与传统双腔导管在接受单肺通气的胸科手术成年患者中的成本效益分析。

A Cost-Effectiveness Analysis Comparing the VivaSight Double-Lumen Tube and a Conventional Double-Lumen Tube in Adult Patients Undergoing Thoracic Surgery Involving One-Lung Ventilation.

作者信息

Larsen Sara, Holm Jimmy Højberg, Sauer Tove Nørgaard, Andersen Claus

机构信息

Aalborg University, Niels Jernes Vej 10, 9220, Aalborg, Denmark.

Odense University Hospital, J.B. Winsløws Vej 4, 5000, Odense, Denmark.

出版信息

Pharmacoecon Open. 2020 Mar;4(1):159-169. doi: 10.1007/s41669-019-0163-y.

Abstract

BACKGROUND

One-lung ventilation (OLV) procedures are essential for most thoracic surgeries, and the most common method is intubation with a conventional double-lumen tube (cDLT) and bronchoscopy to verify correct tube placement.

OBJECTIVE

The objective of this study was to conduct a cost-effectiveness analysis comparing the VivaSight double-lumen tube (DL) and a cDLT for OLV procedures.

METHODS

A cost-effectiveness analysis was conducted from a healthcare sector perspective in Denmark using a decision analytic model to assess the potential effects and costs of using VivaSight-DL as an alternative to a cDLT with a reusable bronchoscope. Costs were determined using a micro-costing approach. The effectiveness measure was the number of times that fiberoptic confirmation of the tube placement during intubation or surgery was unnecessary and thus avoided. The effectiveness input was from a randomized controlled trial (n = 52). Both deterministic and probabilistic sensitivity analyses were conducted to assess the robustness of the results.

RESULTS

Fiberoptic confirmation of tube placement was only necessary in two (6.66%) procedures using VivaSight-DL. The cost of using VivaSight-DL was $US299.96 per procedure versus $US347.61 for a cDLT with a reusable bronchoscope. The incremental cost-effectiveness ratio was - $US51.06 per bronchoscopy avoided. The base-case analysis indicated that the use of VivaSight-DL was cost effective compared with the use of a cDLT with reusable bronchoscope. Sensitivity analyses showed that the results were robust and that VivaSight-DL was more effective and less costly.

CONCLUSION

This study suggests that VivaSight-DL is associated with cost savings and reductions in bronchoscope use to verify correct tube placement. The conclusion is based on the results from a single institution. To clarify whether VivaSight-DL is cost effective in larger or global clinical settings, further economic evaluations should be performed.

摘要

背景

单肺通气(OLV)程序对大多数胸外科手术至关重要,最常见的方法是使用传统双腔管(cDLT)插管并通过支气管镜检查来验证导管位置是否正确。

目的

本研究的目的是进行一项成本效益分析,比较VivaSight双腔管(DL)和cDLT用于OLV程序的情况。

方法

从丹麦医疗保健部门的角度进行成本效益分析,使用决策分析模型评估使用VivaSight-DL替代带有可重复使用支气管镜的cDLT的潜在效果和成本。成本采用微观成本核算方法确定。有效性指标是插管或手术期间无需通过纤维光学确认导管位置从而避免的次数。有效性数据来自一项随机对照试验(n = 52)。进行了确定性和概率性敏感性分析以评估结果的稳健性。

结果

使用VivaSight-DL的程序中只有两例(6.66%)需要通过纤维光学确认导管位置。使用VivaSight-DL的成本为每次程序299.96美元,而使用带有可重复使用支气管镜的cDLT的成本为347.61美元。每避免一次支气管镜检查的增量成本效益比为 - 51.06美元。基础病例分析表明,与使用带有可重复使用支气管镜的cDLT相比,使用VivaSight-DL具有成本效益。敏感性分析表明结果稳健,且VivaSight-DL更有效且成本更低。

结论

本研究表明,VivaSight-DL可节省成本并减少用于验证导管位置是否正确的支气管镜使用次数。该结论基于单个机构的结果。为了阐明VivaSight-DL在更大规模或全球临床环境中是否具有成本效益,应进行进一步的经济评估。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/925d/7018861/e57e91c55952/41669_2019_163_Fig1_HTML.jpg

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