Centre for Molecular Therapeutics, Australian Institute for Tropical Health and Medicine, James Cook University, Cairns, QLD, Australia.
Adv Exp Med Biol. 2019;1154:411-436. doi: 10.1007/978-3-030-18616-6_13.
Trematode infections are among the most neglected tropical diseases despite their worldwide distribution and extraordinary ability to parasitise many different host species and host tissues. Furthermore, these parasites are of great socioeconomic, medical, veterinary and agricultural importance. During the last 10 years, there have been increasing efforts to overcome the lack of information on different "omic" resources such as proteomics and genomics. Herein, we focus on the recent advances in genomics and proteomics from trematodes of human importance, including liver, blood, intestinal and lung flukes. We also provide information on the latest technologies applied to study the biology of trematodes as well as on the resources available for the study of the molecular aspects of this group of helminths.
吸虫感染是最被忽视的热带病之一，尽管它们在世界范围内分布广泛，并且具有寄生许多不同宿主物种和宿主组织的非凡能力。此外，这些寄生虫具有重要的社会经济、医学、兽医和农业意义。在过去的 10 年中，人们越来越努力克服不同“组学”资源（如蛋白质组学和基因组学）信息缺乏的问题。本文重点介绍了人类重要的肝、血、肠和肺吸虫的基因组学和蛋白质组学的最新进展。我们还提供了有关最新技术应用于研究吸虫生物学的信息，以及可用于研究这组寄生虫分子方面的资源。
