Ay Serden, Ünlü Yaşar
Department of General Surgery, KTO Karatay University Faculty of Medicine, Konya-Turkey.
Department of Pathology, Health Sciences University Konya Training and Research Hospital, Konya-Turkey.
Ulus Travma Acil Cerrahi Derg. 2019 Jul;25(4):338-342. doi: 10.14744/tjtes.2019.38265.
The present study was designed to compare the effectiveness of topical silver sulfadiazine (SSD) and Ankaferd Blood Stopper® (ABS) usage in experimental partial-thickness burns in rats.
Twenty-one male Wistar albino rats weighing 250-290 (range: 270+-19) g were used in the present study. A round brass probe that was specifically designed (3×3 cm diameter) was used to induce the burns in rats. After the presence of partial-thickness burns was confirmed, the rats were divided into three groups: Group 1 (ABS group) Ankaferd Blood Stopper® pad, Group 2 (SSD group) silver sulfadiazine (Silverdin®), and Group 3 (Control group) 1% isotonic saline solution-impregnated pad. The healing period was followed up clinically and histopathologically. The day on which 50% and 80% of re-epithelization at first were detected for each rat was also recorded.
The mean times of 50% and 80% of re-epithelization at first were 10.8 days, 13.8 days, and 16.8 days in Groups 1, 2, and 3, respectively (p<0.001), and 16.4 days, 19.7 days, and 25.2 days, respectively (p<0.001). The mean inflammatory scores were also found to be better in the ABS group than in other groups (p<0.05).
Our study showed that ABS has better results for the healing of the burn wound than SSD in experimental partial-thickness burns in rats.
本研究旨在比较局部应用磺胺嘧啶银（SSD）和安卡芬德止血剂（ABS）对大鼠实验性浅度烧伤的疗效。
本研究使用了21只体重250 - 290（范围：270±19）克的雄性Wistar白化大鼠。使用专门设计的圆形黄铜探头（直径3×3厘米）对大鼠进行烧伤诱导。确认存在浅度烧伤后，将大鼠分为三组：第1组（ABS组）使用安卡芬德止血剂垫，第2组（SSD组）使用磺胺嘧啶银（西尔瓦丁®），第3组（对照组）使用浸渍1%等渗盐溶液的垫。对愈合期进行临床和组织病理学随访。还记录了每只大鼠首次检测到50%和80%再上皮化的日期。
第1、2和3组首次50%和80%再上皮化的平均时间分别为10.8天、13.8天和16.8天（p<0.0^01），以及分别为16.4天、19.7天和25.2天（p<0.0^01）。还发现ABS组的平均炎症评分优于其他组（p<0.05）。
我们的研究表明，在大鼠实验性浅度烧伤中，ABS对烧伤创面愈合的效果优于SSD。
