Arslan Kemal, Karahan Omer, Okuş Ahmet, Unlü Yaşar, Eryılmaz Mehmet Ali, Ay Serden, Sevinç Barış
Department of General Surgery, Konya Training and Research Hospital, Konya, Turkey.
Ulus Travma Acil Cerrahi Derg. 2012 Sep;18(5):376-83. doi: 10.5505/tjtes.2012.45381.
We aimed to compare the effects of topical zinc oxide and topical silver sulfadiazine in the treatment of partial-thickness burn wounds.
The study was conducted with 20 New Zealand rabbits, and burn wounds were created by a brass probe. The animals were randomly divided into two groups. The burns were treated with zinc oxide (Group O) or silver sulfadiazine (Group S) with daily application. The wound healing process was followed both clinically and histopathologically. We determined the days at which 50% and 80% re-epithelization was observed.
The mean time for 50% and 80% re-epithelization was 21.4 and 25.4 days in Group O and 25.8 and 30.2 days in Group S, respectively (p<0.001). The mean score for wound colonization was lower in Group O. The difference was statistically significant at weeks 2, 3, 4, and 6 (p<0.001). In the histopathological examination, the thicknesses of the epidermis, dermis and scar tissue were 0.12 mm, 3.80 mm and 244 mm in Group O, and 0.16 mm, 4.76 mm and 3.16 mm in Group S, respectively (p<0.001).
In this experimental burn study, zinc oxide was more effective than silver sulfadiazine in terms of epithelization, dermis maturation and scar formation.
我们旨在比较局部应用氧化锌和磺胺嘧啶银治疗浅Ⅱ度烧伤创面的效果。
该研究使用了20只新西兰兔，通过铜探针造成烧伤创面。将动物随机分为两组。烧伤创面分别用氧化锌（O组）或磺胺嘧啶银（S组）每日进行处理。临床和组织病理学观察创面愈合过程。我们确定观察到50%和80%再上皮化的天数。
O组50%和80%再上皮化的平均时间分别为21.4天和25.4天，S组分别为25.8天和30.2天（p<0.001）。O组创面定植的平均评分较低。在第2、3、4和6周时差异具有统计学意义（p<0.001）。组织病理学检查中，O组表皮、真皮和瘢痕组织的厚度分别为0.12mm、3.80mm和244mm，S组分别为0.16mm、4.76mm和3.16mm（p<0.001）。
在本实验性烧伤研究中，在再上皮化、真皮成熟和瘢痕形成方面，氧化锌比磺胺嘧啶银更有效。
