Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
Biostatistics Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
Respirology. 2020 Mar;25(3):289-297. doi: 10.1111/resp.13643. Epub 2019 Jul 11.
Early menarche is increasing in prevalence worldwide, prompting clinical and public health interest on its links with pulmonary function. We aimed to investigate the relationship between early menarche and lung function in middle age.
The population-based Tasmanian Longitudinal Health Study (born 1961; n = 8583), was initiated in 1968. The 5th Decade follow-up data (mean age: 45 years) included age at menarche and complex lung function testing. The 6th Decade follow-up (age: 53 years) repeated spirometry and gas transfer factor. Multiple linear regression and mediation analyses were performed to determine the association between age at menarche and adult lung function and investigate biological pathways, including the proportion mediated by adult-attained height.
Girls reporting an early menarche (<12 years) were measured to be taller with greater lung function at age 7 years compared with those reporting menarche ≥12 years. By 45 years of age, they were shorter and had lower post-bronchodilator (BD) forced expiratory volume in 1 s (adjusted mean difference: -133 mL; 95% CI: -233, -33), forced vital capacity (-183 mL; 95% CI: -300, -65) and functional residual capacity (-168 mL; 95% CI: -315, -21). Magnitudes of spirometric deficits were similar at age 53 years. Forty percent of these total effects were mediated through adult-attained height.
Early menarche was associated with reduced adult lung function. This is the first study to investigate post-BD outcomes and quantify the partial role of adult height in this association.
全球范围内，初潮年龄提前的现象越来越普遍，这引起了临床和公共卫生领域对其与肺功能之间关联的关注。本研究旨在探讨中年时初潮年龄与肺功能之间的关系。
本研究基于人群的塔斯马尼亚纵向健康研究（1961 年出生；n=8583），该研究于 1968 年启动。在第 5 个 10 年随访（平均年龄：45 岁）中，包含了初潮年龄和复杂的肺功能检测数据。在第 6 个 10 年随访（年龄：53 岁）中，重复了肺活量测定和气体转移因子检测。采用多元线性回归和中介分析来确定初潮年龄与成人肺功能之间的关联，并探讨生物学途径，包括成人身高获得所介导的比例。
与报告初潮年龄≥12 岁的女孩相比，报告初潮年龄较早（<12 岁）的女孩在 7 岁时身高更高，肺功能更强。到 45 岁时，她们的身高较矮，且用力呼气量（BD 后）（校正平均差异：-133mL；95%CI：-233，-33）、用力肺活量（-183mL；95%CI：-300，-65）和功能残气量（-168mL；95%CI：-315，-21）更低。在 53 岁时，这些肺活量的缺陷程度相似。这些总效应的 40%是通过成人身高获得来介导的。
初潮年龄与成人肺功能降低有关。这是第一项研究调查 BD 后结果并量化成人身高在这种关联中的部分作用的研究。
