Department of Cell and Molecular Pharmacology & Experimental Therapeutics , Medical University of South Carolina , Charleston , South Carolina 29425 , United States.
ACS Sens. 2019 Jul 26;4(7):1791-1797. doi: 10.1021/acssensors.9b00274. Epub 2019 Jul 12.
A pyrene-containing salicylic acid derivative () was found to be low in fluorescence, but its derivative pyrene-containing methyl salicylate () was found to be highly fluorescent in aqueous solution. This derivative has been tested in solution and found to be superior in the fluorogenic assay of pharmaceutical compounds, detection of chemical warfare agents, a preliminary toxicology test, mutagenicity of medicinal compounds, and other chemical analyses, including trimethylsilyl diazomethane; alkyl bromides and iodides; a sulfur mustard mimic 2-chloroethyl ethyl sulfide; and anticancer drugs, busulfan and pipobroman. The salicylic acid derivative () was applied as a fluorogenic probe for the detection of alkylating agents by esterification and generating fluorescence at 475 nm in solutions at low concentrations.
一种含芘的水杨酸衍生物（）荧光较弱，但它的衍生物含芘的甲基水杨酸酯（）在水溶液中具有很强的荧光。该衍生物已在溶液中进行了测试，在药物化合物的荧光分析检测、化学战剂的检测、初步毒理学测试、药物化合物的致突变性以及包括三甲基硅重氮甲烷在内的其他化学分析中表现优异；烷基溴化物和碘化物；一种类似芥子气的 2-氯乙基乙基硫醚；以及抗癌药物白消安和哌泊溴烷。水杨酸衍生物（）被用作通过酯化检测烷化剂的荧光探针，在低浓度溶液中在 475nm 处产生荧光。
