Process and Technology Development Division, Defence Research and Development Establishment , Jhansi Road, Gwalior 474002, India.
Anal Chem. 2018 Jan 16;90(2):1417-1422. doi: 10.1021/acs.analchem.7b04882. Epub 2018 Jan 4.
Since the first use of chemical warfare agents (CWA) (1915) to the recent attacks in Syria (2017) on mankind, there have been many incidents where CWA have claimed thousands of lives and left many more contaminated. In order to provide the appropriate and immediate medical counter measure to the victims, the exact classification of these chemical agents within few minutes on the field itself using a rapid and simple detection technique is extremely important to save the lives of the effected people. This has motivated all of us to explore the novel strategies/detection systems that can be field deployable with better selectivity and greater sensitivity. In view of this, we present a novel chemosensor, 3,6-bis(dimethylamino)-9(10H)-acridine thione (1), that can detect mustard gas and its simulant by both chromogenic and fluorogenic methods. For the first time, a single probe was able to demonstrate the detection with unprecedented selectivity over most probable interferences (nerve agents and alkylating agents) including solvents, acids, and bases which are routinely present in the environment. The desired level of sensitivity by naked eyes (0.04 mg/mL), UV spectroscopy (0.02 mg/mL), and fluorescence spectroscopy (0.005 mg/mL) makes this method truly field deployable. For the spot detection on the affected areas, a handy and potable chemosensor kit was also fabricated. This paper provides a simple, highly specific, and easy to use method in "actual sense" that not only detects the agents in the solution phase but also in the contaminated samples.
自 1915 年首次使用化学战剂（CWA）以来，到 2017 年叙利亚最近发生的袭击事件，CWA 已经造成数千人死亡，更多人受到污染。为了向受害者提供适当和及时的医疗对策，在现场本身使用快速简单的检测技术在几分钟内准确地对这些化学剂进行分类，对于拯救受影响者的生命至关重要。这促使我们所有人探索新的策略/检测系统，这些系统可以具有更好的选择性和更高的灵敏度，并可以现场部署。有鉴于此，我们提出了一种新型化学传感器，3,6-双（二甲氨基）-9（10H）-吖啶硫酮（1），它可以通过比色法和荧光法检测芥子气及其模拟物。首次，单个探针能够以无与伦比的选择性检测到最可能的干扰物（神经毒剂和烷化剂），包括环境中通常存在的溶剂、酸和碱。肉眼（0.04mg/mL）、紫外光谱（0.02mg/mL）和荧光光谱（0.005mg/mL）所需的灵敏度水平使这种方法真正可以现场部署。为了在受影响的区域进行现场检测，还制造了一种方便且便携的化学传感器套件。本文提供了一种简单、高度特异和易于使用的方法，不仅可以检测溶液相中的试剂，还可以检测污染样品中的试剂。
