Ege University, School of Dentistry, Department of Oral Surgery, Erzene AVE, 35040 Bornova, İzmir, Turkey.
J Stomatol Oral Maxillofac Surg. 2020 Apr;121(2):118-123. doi: 10.1016/j.jormas.2019.07.002. Epub 2019 Jul 9.
The aim of this study was to evaluate the effectiveness of concentrated growth factor(CGF) on soft tissue healing and postoperative side effects following third molar surgery.
This study was designed on 60 patients as a randomized single-blind clinical trial. The predictor variable was the implementation of CGF fibrin matrix, which was categorized as CGF and non-CGF. The primary outcome variable of the study was the healing of soft tissue around the extraction socket. The secondary outcome variables were pain, swelling and trismus. Data were analyzed using the non-parametric Brunner and Langer model. Statistical significance was set at P<.001.
Sixty patients (39 female, 21 male; mean age 25.82) with impacted mandibular third molars participated in the study. Statistical analysis revealed that there were significant differences between the control and test groups with regard to soft tissue healing, postoperative pain, swelling, and trismus (P<0.001).
The application of CGF accelerates soft tissue healing and is beneficial in minimising postoperative side effects, particularly pain, swelling and trismus, after extraction of mandibular third molars.
NCT03913884.
本研究旨在评估浓缩生长因子（CGF）在第三磨牙手术后软组织愈合和术后不良反应方面的有效性。
这是一项设计为随机单盲临床试验的 60 名患者研究。预测变量是 CGF 纤维蛋白基质的实施，分为 CGF 和非 CGF。研究的主要结局变量是拔牙窝周围软组织的愈合。次要结局变量是疼痛、肿胀和牙关紧闭。使用非参数 Brunner 和 Langer 模型分析数据。统计显著性设置为 P<.001。
60 名（39 名女性，21 名男性；平均年龄 25.82 岁）有阻生下颌第三磨牙的患者参加了这项研究。统计分析显示，在软组织愈合、术后疼痛、肿胀和牙关紧闭方面，对照组和试验组之间存在显著差异（P<0.001）。
CGF 的应用可加速软组织愈合，并有利于减少下颌第三磨牙拔除术后的术后不良反应，特别是疼痛、肿胀和牙关紧闭。
NCT03913884。
