Zhou BoQiao, Luo XianYan
Department of Dermatology, Hangzhou Third People's Hospital, Zhejiang, Hangzhou, China.
J Cosmet Dermatol. 2025 Apr;24(4):e70203. doi: 10.1111/jocd.70203.
To evaluate the therapeutic potential of locally injecting concentrated growth factor (CGF) into flaps for treating flap ischemia-reperfusion injury (FIRI) following reconstructive surgery.
Nineteen patients with FIRI were enrolled in this study. After clinical identification of ischemia-reperfusion (IR) injury, CGF was prepared from each patient's autologous blood and locally injected into the affected flap tissue. Flap viability was assessed using clinical indicators such as color, texture, and capillary refill. Patients were followed for 6 months postoperatively to assess long-term outcomes.
Seven days after CGF injection, 18 of 19 patients demonstrated complete flap survival. In one case, total necrosis occurred due to hematoma formation and insufficient dressing compression, but healing was achieved through dressing changes. Overall, patients showed improvements in flap color (from dark to ruddy), texture (softened), and skin tension (decreased), with visible wrinkle formation. Long-term follow-up confirmed satisfactory appearance and functional outcomes.
Local injection of CGF effectively enhances flap survival by promoting recovery from IR injury. This strategy may offer a promising adjunctive therapy in reconstructive procedures to improve tissue viability and healing.
评估局部注射浓缩生长因子（CGF）至皮瓣用于治疗重建手术后皮瓣缺血再灌注损伤（FIRI）的治疗潜力。
本研究纳入了19例FIRI患者。在临床确诊缺血再灌注（IR）损伤后，从每位患者的自体血液中制备CGF，并局部注射到受影响的皮瓣组织中。使用颜色、质地和毛细血管再充盈等临床指标评估皮瓣活力。术后对患者进行6个月的随访，以评估长期结果。
CGF注射7天后，19例患者中有18例皮瓣完全存活。1例因血肿形成和敷料压迫不足导致完全坏死，但通过更换敷料实现愈合。总体而言，患者的皮瓣颜色（从暗红变为红润）、质地（变软）和皮肤张力（降低）均有改善，可见皱纹形成。长期随访证实外观和功能结果令人满意。
局部注射CGF可通过促进IR损伤的恢复有效提高皮瓣存活率。该策略可能为重建手术提供一种有前景的辅助治疗方法，以改善组织活力和愈合。
