富血小板纤维蛋白和浓缩生长因子对根管显微手术后早期骨愈合影响的体积学评价：一项随机对照试验。

Volumetric evaluation of effects of platelet-rich fibrin and concentrated growth factor on early bone healing after endodontic microsurgery: a randomized controlled trial.

机构信息

Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University, Gwangju, Korea.

Department of Periodontology, School of Dentistry, Chosun University, Gwangju, Korea.

出版信息

BMC Oral Health. 2023 Oct 29;23(1):821. doi: 10.1186/s12903-023-03530-w.

BACKGROUND

This randomized controlled clinical trial compared the effects of platelet-rich fibrin (PRF) and concentrated growth factor (CGF) on early bone healing after endodontic microsurgery.

METHODS

Eighteen patients with an isolated periapical lesion < 10 mm in the maxillary anterior region were randomly assigned to three groups: control, PRF, or CGF. Endodontic microsurgery was performed and PRF or CGF membranes were placed over the bone defects in the experimental groups. The volume of the bone defect at postoperative one week, three months, and six months was evaluated using cone-beam computed tomography and Mimics software. The results were statistically analyzed using the Kruskal-Wallis test and post-hoc Mann-Whitney U test with Bonferroni correction.

RESULTS

At the three-month follow-up, the PRF and CGF groups showed significantly greater bone healing compared with the control group (p > 0.05). However, no significant difference was observed between the PRF and CGF groups. At the six-month follow-up, no significant differences were observed between the groups.

CONCLUSIONS

These results suggested that PRF and CGF promote early bone healing after endodontic microsurgery.

背景

本随机对照临床试验比较了富血小板纤维蛋白（PRF）和浓缩生长因子（CGF）对根管显微手术后早期骨愈合的影响。

方法

将 18 名上颌前区孤立性根尖病变<10mm 的患者随机分为三组：对照组、PRF 组或 CGF 组。对所有患者行根管显微手术，并在实验组的骨缺损处放置 PRF 或 CGF 膜。术后一周、三个月和六个月时，使用锥形束 CT 和 Mimics 软件评估骨缺损体积。采用 Kruskal-Wallis 检验和事后 Mann-Whitney U 检验（Bonferroni 校正）对结果进行统计学分析。