Department of Oral and Maxillofacial Surgery, School of Dentistry, Chosun University, Gwangju, Korea.
Department of Periodontology, School of Dentistry, Chosun University, Gwangju, Korea.
BMC Oral Health. 2023 Oct 29;23(1):821. doi: 10.1186/s12903-023-03530-w.
This randomized controlled clinical trial compared the effects of platelet-rich fibrin (PRF) and concentrated growth factor (CGF) on early bone healing after endodontic microsurgery.
Eighteen patients with an isolated periapical lesion < 10 mm in the maxillary anterior region were randomly assigned to three groups: control, PRF, or CGF. Endodontic microsurgery was performed and PRF or CGF membranes were placed over the bone defects in the experimental groups. The volume of the bone defect at postoperative one week, three months, and six months was evaluated using cone-beam computed tomography and Mimics software. The results were statistically analyzed using the Kruskal-Wallis test and post-hoc Mann-Whitney U test with Bonferroni correction.
At the three-month follow-up, the PRF and CGF groups showed significantly greater bone healing compared with the control group (p > 0.05). However, no significant difference was observed between the PRF and CGF groups. At the six-month follow-up, no significant differences were observed between the groups.
These results suggested that PRF and CGF promote early bone healing after endodontic microsurgery.
本随机对照临床试验比较了富血小板纤维蛋白（PRF）和浓缩生长因子（CGF）对根管显微手术后早期骨愈合的影响。
将 18 名上颌前区孤立性根尖病变<10mm 的患者随机分为三组：对照组、PRF 组或 CGF 组。对所有患者行根管显微手术，并在实验组的骨缺损处放置 PRF 或 CGF 膜。术后一周、三个月和六个月时，使用锥形束 CT 和 Mimics 软件评估骨缺损体积。采用 Kruskal-Wallis 检验和事后 Mann-Whitney U 检验（Bonferroni 校正）对结果进行统计学分析。
在三个月随访时，PRF 组和 CGF 组的骨愈合明显优于对照组（p>0.05）。然而，PRF 组和 CGF 组之间无显著差异。在六个月随访时，各组之间无显著差异。
这些结果表明，PRF 和 CGF 可促进根管显微手术后的早期骨愈合。
