DNA非整倍体细胞学在口腔癌无创检测中的当前证据。
Current evidence on DNA aneuploidy cytology in noninvasive detection of oral cancer.
作者信息
Shi Linjun, Wang Yufeng, Li Chenxi, Liu Wei
机构信息
Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Stomatology, Shanghai, China.
Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
出版信息
Oral Oncol. 2020 Feb;101:104367. doi: 10.1016/j.oraloncology.2019.07.010. Epub 2019 Jul 10.
DNA-aneuploidy cytology as a promising noninvasive tool in diagnosing oral precancer and cancer has been proposed in 2015. In this letter, we identified 9 studies on DNA aneuploidy cytology with special emphasis on using fresh tissue sample in detection of oral precancer and cancer. Evidence was updated as follows, for detection of OSCC in general oral lesions, the pooled sensitivity and specificity was 84.8 and 99.0 respectively; for discrimination of dysplasia and OSCC form oral lesions, the sensitivity and specificity was 75.7 and 76.8 respectively. On the whole, current evidence on the theme is not robust, and multicenter prospective studies are needed to consolidate the evidence.
2015年有人提出，DNA非整倍体细胞学作为一种有前景的非侵入性工具，可用于诊断口腔癌前病变和癌症。在这封信中，我们鉴定了9项关于DNA非整倍体细胞学的研究，特别强调使用新鲜组织样本检测口腔癌前病变和癌症。证据更新如下：对于一般口腔病变中口腔鳞状细胞癌（OSCC）的检测，合并敏感度和特异度分别为84.8和99.0；对于区分发育异常和口腔病变中的OSCC，敏感度和特异度分别为75.7和76.8。总体而言，目前关于该主题的证据并不充分，需要多中心前瞻性研究来巩固这些证据。
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