Viral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Sci Immunol. 2019 Jul 12;4(37). doi: 10.1126/sciimmunol.aav0492.
Barriers between circulation and the central nervous system (CNS) play a key role in the development and modulation of CNS immune responses. Structural variations in the vasculature traversing different anatomical regions within the CNS strongly influence where and how CNS immune responses first develop. Here, we provide an overview of cerebrovascular anatomy, focusing on the blood-CNS interface and how anatomical variations influence steady-state immunology in the compartment. We then discuss how CNS vasculature is affected by and influences the development of different pathophysiological states, such as CNS autoimmune disease, cerebrovascular injury, cerebral ischemia, and infection.
循环系统和中枢神经系统 (CNS) 之间的障碍在 CNS 免疫反应的发展和调节中起着关键作用。穿过 CNS 内不同解剖区域的脉管系统的结构变化强烈影响 CNS 免疫反应最初发展的位置和方式。在这里，我们提供了对脑血管解剖结构的概述，重点介绍了血液-CNS 界面以及解剖变异如何影响隔室中的稳态免疫学。然后，我们讨论了 CNS 血管系统如何受到不同病理生理状态（如 CNS 自身免疫性疾病、脑血管损伤、脑缺血和感染）的影响以及反过来如何影响这些状态的发展。
